DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp8

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_032637.3	Gene:	Mmp8 / 17394	MGIID:	1202395	Length:	465	Species:	Mus musculus

Alignment Length:	719	Identity:	185/719 - (25%)
Similarity:	268/719 - (37%)	Gaps:	274/719 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LATL-LALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGAL 70
            |.|| |.:|..:.......:|..       ...|..|||      .|||.:|..||.:...:.
Mouse     4 LKTLPLLIFLHTQLANAFPVPEH-------LEEKNIKTA------ENYLRKFYNLPSNQFRSS-- 53

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
            |....:.|.::.:|.|.::..||::|:||..:::.|||||.|  |.|
Mouse    54 RNATMVAEKLKEMQRFFSLAETGKLDAATMGIMEMPRCGVPD--SGD------------------ 98

  Fly   136 RFALQ--GPKWSRTDLTWSMVNRSMPDASKVERMVQTALD----VWANHSKLTFREVYSDQADIQ 194
             |.|.  .|||:.|:||:.::|.: |..|:.|  |:||::    ||:..|.|||.|:...:|||.
Mouse    99 -FLLTPGSPKWTHTNLTYRIINHT-PQLSRAE--VKTAIEKAFHVWSVASPLTFTEILQGEADIN 159

  Fly   195 ILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHEL 259
            |.|..|.|||...||||..:|||||.||:|.|||||||::|||     :.||...|...||.||.
Mouse   160 IAFVSRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDSEETW-----TQDSKNYNLFLVAAHEF 219

  Fly   260 GHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTT 323
            ||||||:||..|.|:|:|.|...|.:. :||.||..|||.:||
Mouse   220 GHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYG---------------------- 262

  Fly   324 MRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEE 388
                              ||:|
Mouse   263 ------------------PSDN------------------------------------------- 266

  Fly   389 RQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQ 453

Mouse   267 ----------------------------------------------------------------- 266

  Fly   454 EDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMT 518
                                     |:.||..:||:                         :|..
Mouse   267 -------------------------PIQPTGPSTPK-------------------------ACDP 281

  Fly   519 Y--YDAISIIRGELFIFRGPYLWR----IGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQR 577
            :  :||.:.:|||::.|:..|.||    :.|..|     ..|...|..||..|   .|.||:..|
Mouse   282 HLRFDATTTLRGEIYFFKDKYFWRRHPQLRTVDL-----NFISLFWPFLPNGL---QAAYEDFDR 338

  Fly   578 QIVF-FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDY 641
            .:|| |.||:|:..:...|..|:|:.:::.|.|.::..|||:.  .:|.:||.......||.|:.
Mouse   339 DLVFLFKGRQYWALSGYDLQQGYPRDISNYGFPRSVQAIDAAV--SYNGKTYFFINNQCWRYDNQ 401

  Fly   642 TGQVELDYPRDM-SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAH-ARAKLSARRW 704
            ...::..||:.: |::.||...:||.| ..|....||....|:.||....:|.. ||:.|    |
Mouse   402 RRSMDPGYPKSIPSMFPGVNCRVDAVF-LQDSFFLFFSGPQYFAFNFVSHRVTRVARSNL----W 461

  Fly   705 MQCA 708
            :.|:
Mouse   462 LNCS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	78/162 (48%)
		ZnMc_MMP	143..301	CDD:239805	78/162 (48%)
		HX	513..707	CDD:238046	60/202 (30%)
Mmp8	NP_032637.3	PG_binding_1	31..86	CDD:279773	18/62 (29%)
		Cysteine switch. /evidence=ECO:0000250	89..96		6/8 (75%)
		Peptidase_M10	107..262	CDD:278824	78/162 (48%)
		ZnMc_MMP	107..262	CDD:239805	78/162 (48%)
		HX	276..464	CDD:238046	61/227 (27%)
		Hemopexin 1	276..325		15/78 (19%)
		Hemopexin 2	326..372		16/48 (33%)
		Hemopexin 3	374..420		12/47 (26%)
		Hemopexin 4	421..464		14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.950