DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp7

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_034940.2	Gene:	Mmp7 / 17393	MGIID:	103189	Length:	267	Species:	Mus musculus

Alignment Length:	304	Identity:	113/304 - (37%)
Similarity:	155/304 - (50%)	Gaps:	50/304 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ATLLALFAQSMCI--QELSLP-PEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGA 69
            |..|.||. .:|:  ..|:|| .:.:...:|.:.::|:         |||.:|  .|........
Mouse     3 AMQLTLFC-FVCLLPGHLALPLSQEAGDVSAHQWEQAQ---------NYLRKF--YPHDSKTKKV 55

  Fly    70 LRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRV 134
            ....|.|||    :|.|..:.:||::......::|||||||.|                     |
Mouse    56 NSLVDNLKE----MQKFFGLPMTGKLSPYIMEIMQKPRCGVPD---------------------V 95

  Fly   135 RRFAL--QGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQI 195
            ..::|  ..|||....:|:.:|:.: .|..:  |:::|:.||.:|:....|.|:.|....|||.|
Mouse    96 AEYSLMPNSPKWHSRIVTYRIVSYT-SDLPRIVVDQIVKKALRMWSMQIPLNFKRVSWGTADIII 159

  Fly   196 LFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELG 260
            .||||.|||.:.|||||..|.|||.||.|.|||||||.||.|. |||   ..|.|||..|.||.|
Mouse   160 GFARRDHGDSFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWT-DGE---DAGVNFLFAATHEFG 220

  Fly   261 HSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTK 303
            |||||:||::|..||:|.||.:.... :|..||..|||:|||.:
Mouse   221 HSLGLSHSSVPGTVMYPTYQRDYSEDFSLTKDDIAGIQKLYGKR 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	77/160 (48%)
		ZnMc_MMP	143..301	CDD:239805	77/160 (48%)
		HX	513..707	CDD:238046
Mmp7	NP_034940.2	PG_binding_1	34..85	CDD:279773	14/65 (22%)
		Peptidase_M10	106..262	CDD:278824	77/160 (48%)
		ZnMc_MMP	106..262	CDD:239805	77/160 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920