DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp24

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_034938.3	Gene:	Mmp24 / 17391	MGIID:	1341867	Length:	618	Species:	Mus musculus

Alignment Length:	721	Identity:	200/721 - (27%)
Similarity:	290/721 - (40%)	Gaps:	203/721 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            ||.|.....|:            .||..:.|...|.:.....|:|..:.||...:....||.:..
Mouse    26 LLPLLPALCCL------------AAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGK 78

  Fly    75 QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFAL 139
            .|:.|:.::|.|..|.|||.:|..|...::||||||.|            :..:....|.:|:||
Mouse    79 ALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPD------------HPHLSRRRRNKRYAL 131

  Fly   140 QGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHSKLTFREV-----YSD--QADIQI 195
            .|.||.:..:|:|:.|.: |...:::  :.::.|.|||...:.|||.||     .||  :|||.|
Mouse   132 TGQKWRQKHITYSIHNYT-PKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMI 195

  Fly   196 LFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELG 260
            .||...|||...|||.|..||||::||.|.|||.|||:||.|.....:.|  |.:...||:||||
Mouse   196 FFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHD--GNDLFLVAVHELG 258

  Fly   261 HSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTM 324
            |:|||.||..|.|:|.|:||..|... .||.||..|||::||.      |.:|...|....|..:
Mouse   259 HALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP------PAEPLEPTRPLPTLPV 317

  Fly   325 RAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEER 389
            |.:            ::||                              ||:|
Mouse   318 RRI------------HSPS------------------------------ERKH------------ 328

  Fly   390 QRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQE 454
                                          ||:|     ||                  .|....
Mouse   329 ------------------------------ERHP-----RP------------------PRPPLG 340

  Fly   455 DRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTY 519
            ||                      |.||.|                           ||:.|...
Mouse   341 DR----------------------PSTPGA---------------------------KPNICDGN 356

  Fly   520 YDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIG 584
            ::.:::.|||:|:|:..:.||:..:.:..|||.:|.:.|..||   .::||.||....:.|||.|
Mouse   357 FNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLP---ARIDAAYERADGRFVFFKG 418

  Fly   585 REYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDY 649
            .:|:||..|.:.||:|..|..||.......||.:..|....:||...|..|||..:.....:..|
Mouse   419 DKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGY 483

  Fly   650 PRDMSIWSGVGYNIDAAFQYLDG-KTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANE 713
            |:.:::|.|:......||...:| .|||:|...||:|::.::.|.....:...|.||.|.:...|
Mouse   484 PKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVE 548

  Fly   714 VDDEQR 719
            ...|:|
Mouse   549 RRKERR 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	74/167 (44%)
		ZnMc_MMP	143..301	CDD:239805	74/167 (44%)
		HX	513..707	CDD:238046	61/194 (31%)
Mmp24	NP_034938.3	PG_binding_1	55..107	CDD:307564	16/51 (31%)
		Cysteine switch. /evidence=ECO:0000250	110..117		6/18 (33%)
		Peptidase_M10	135..300	CDD:306839	74/167 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..352		27/217 (12%)
		HX	350..542	CDD:238046	61/194 (31%)
		Hemopexin 1	350..398		14/47 (30%)
		Hemopexin 2	399..444		19/47 (40%)
		Hemopexin 3	446..494		13/47 (28%)
		Hemopexin 4	495..542		14/46 (30%)
		DUF3377	548..618	CDD:314687	3/7 (43%)
		PDZ-binding	616..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.950