DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and Mmp16

DIOPT Version :10

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_062698.2 Gene:Mmp16 / 17389 MGIID:1276107 Length:607 Species:Mus musculus


Alignment Length:671 Identity:196/671 - (29%)
Similarity:288/671 - (42%) Gaps:200/671 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDR-RSA 116
            :|.::.|||.:|.....||:.:.::.|:.::|.|..|.:||::|..|...::||||||.|: |.:
Mouse    46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGS 110

  Fly   117 DSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHS 179
            ..|           |:|.:|:||.|.||....:|:|:.|.: |.....|  |.::.|.|||.|.:
Mouse   111 SKF-----------NIRRKRYALTGQKWQHKHITYSIKNVT-PKVGDPETRRAIRRAFDVWQNVT 163

  Fly   180 KLTFREV-YSD------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237
            .|||.|| ||:      ..||.|:||...|||...|||.|..||||::||.|.|||.|||:||.|
Mouse   164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPW 228

  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYG 301
            .....:.|  |.:...||:|||||:|||.||..|.|:|.|:||..|... .||:||..|||::||
Mouse   229 TLGNPNHD--GNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291

  Fly   302 TKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEK 366
            ..:|...|.:|..|...          :|:..||                               
Mouse   292 PPDKIPPPTRPLPTVPP----------HRSVPPA------------------------------- 315

  Fly   367 ERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPR 431
                  :.|||                                                  :||:
Mouse   316 ------DPRRH--------------------------------------------------DRPK 324

  Fly   432 ERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKP-Y 495
                                                           |..|       ||.:| |
Mouse   325 -----------------------------------------------PPRP-------PTGRPSY 335

  Fly   496 PTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
            |..             ||:.|...::.::|:|.|:|:|:..:.||:..:.:.:|||.:|...|..
Mouse   336 PGA-------------KPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRG 387

  Fly   561 LPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASL--GLPPTLTH-IDASFVWG 622
            ||.:   :||||||.....|||.|.:|:||....|.||:|..|.:|  |:||   | ||::..|.
Mouse   388 LPPS---IDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPP---HGIDSAIWWE 446

  Fly   623 HNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLD-GKTYFFKNLGYWEFN 686
            ...:||...|..|||..:....::..||:.::||.|:..:...||.:.: |.|||:|...||:||
Mouse   447 DVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511

  Fly   687 DDRMKVAHARAKLSARRWMQC 707
            :..:||.....:...:.:|.|
Mouse   512 NQILKVEPGYPRSILKDFMGC 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 PG_binding_1 52..103 CDD:460223 15/49 (31%)
Peptidase_M10 143..301 CDD:425668 76/167 (46%)
HX 513..707 CDD:238046 67/197 (34%)
Mmp16NP_062698.2 PG_binding_1 46..96 CDD:460223 15/49 (31%)
Cysteine switch. /evidence=ECO:0000250 99..106 5/6 (83%)
Peptidase_M10 126..291 CDD:425668 76/167 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..340 26/222 (12%)
PHA03247 <292..338 CDD:223021 19/196 (10%)
HX 340..532 CDD:238046 67/197 (34%)
Hemopexin 1 340..388 14/47 (30%)
Hemopexin 2 389..434 20/47 (43%)
Hemopexin 3 436..484 16/50 (32%)
Hemopexin 4 485..532 14/46 (30%)
DUF3377 537..607 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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