DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and Mmp15

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_032635.1 Gene:Mmp15 / 17388 MGIID:109320 Length:657 Species:Mus musculus


Alignment Length:710 Identity:204/710 - (28%)
Similarity:288/710 - (40%) Gaps:201/710 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 HSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEI 95
            |.||   ||.|:...:|    |:|..:.|||:.......:|:...|..|:..:|||..|.|||.:
Mouse    37 HGTA---SKDAEVYAAE----NWLRLYGYLPQPSRHMSTMRSAQILASALAEMQSFYGIPVTGVL 94

  Fly    96 DSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR--RFALQGPKWSRTDLTWSMVN--- 155
            |..|...:::|||||          ||.....:.:|:|.|  |:.|.|..|:...||:|:.|   
Mouse    95 DEETKTWMKRPRCGV----------PDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQNYTE 149

  Fly   156 -----RSMPDASKVERMVQTALDVWANHSKLTFREV-YSD-------QADIQILFARRAHGDGYK 207
                 .||       ..|:.|..||...:.|.|:|| |.|       :|||.:|||...|||...
Mouse   150 KLGWYNSM-------EAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDSSP 207

  Fly   208 FDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPD 272
            |||.|..||||::||.|.|||.||||||.|.|  .|.|.||.:...||:|||||:|||.||:.|.
Mouse   208 FDGVGGFLAHAYFPGPGLGGDTHFDADEPWTF--SSTDLHGISLFLVAVHELGHALGLEHSSNPS 270

  Fly   273 AVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAY 336
            |:|.|:||..:... .||:||..|||||||:.:.     |||.|                 :|. 
Mouse   271 AIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDG-----KPQPT-----------------RPL- 312

  Fly   337 WPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQ 401
                 |:..|                                                       
Mouse   313 -----PTVRP------------------------------------------------------- 317

  Fly   402 ERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQL 466
                               |.|.:..::|                                    
Mouse   318 -------------------RRPGRPDHQP------------------------------------ 327

  Fly   467 EWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELF 531
                     .|.|..|.....|....||.|.  .|.....:|.:..|:.|...:|.::::|||:|
Mouse   328 ---------PRPPQPPHPGGKPERPPKPGPP--PQPRATERPDQYGPNICDGNFDTVAVLRGEMF 381

  Fly   532 IFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLA 596
            :|:|.:.||:..:.:.:.||..|...|..||.|   :.|.||.:....|||.|..|::|....|.
Mouse   382 VFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGN---ISAAYERQDGHFVFFKGNRYWLFREANLE 443

  Fly   597 PGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGY 661
            ||:|:||:|.|.......||.:..|.....|:......|||.::.|...:..||:.:|:|.|:..
Mouse   444 PGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPT 508

  Fly   662 NIDAAFQYLDGK-TYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRW 720
            :...||...|.. |||:|...||:||::|:::.....|...|.:|.|   ...|:...||
Mouse   509 SPKGAFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGC---QEHVEPRSRW 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 79/174 (45%)
ZnMc_MMP 143..301 CDD:239805 79/174 (45%)
HX 513..707 CDD:238046 63/194 (32%)
Mmp15NP_032635.1 Hemopexin 2 412..457 19/47 (40%)
Hemopexin 3 459..507 13/47 (28%)
Hemopexin 4 508..555 15/46 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..599 2/5 (40%)
DUF3377 <632..657 CDD:288690
PG_binding_1 43..102 CDD:279773 19/62 (31%)
Cysteine switch. /evidence=ECO:0000250 105..112 6/16 (38%)
Peptidase_M10 134..300 CDD:278824 79/174 (45%)
ZnMc_MMP 135..300 CDD:239805 79/173 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 26/218 (12%)
HX 363..555 CDD:238046 63/194 (32%)
Hemopexin 1 363..411 15/47 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 149 1.000 Domainoid score I4394
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 1 1.000 - - FOG0000840
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3504
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.950

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