Protein Alignment Mmp2 and Mmp13

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_032633.1
• Gene: Mmp13 / 17386
• MGIID: 1340026
• Length: 472
• Species: Mus musculus
• Alignment Length: 668
• Identity: 170/668 - (25%)
• Similarity: 248/668 - (37%)
• Gaps: 276/668 - (41%)

  Fly    47 EDIMY--NYLMQFDY-------LPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARL 102
            ||:::  :||..:.:       |.||.:.:    |.|:|:|    :|||..:.|||::|..|..:
Mouse    35 EDLVFAEHYLKSYYHPATLAGILKKSTVTS----TVDRLRE----MQSFFGLEVTGKLDDPTLDI 91

  Fly   103 IQKPRCGVGDRRSADSFSPDNLYHEIGS-NVRVRRFALQGPKWSRTDLTWSMVNRSMPDA--SKV 164
            ::||||||.|               :|. ||..|..     |||:|:||:.:||.: ||.  |:|
Mouse    92 MRKPRCGVPD---------------VGEYNVFPRTL-----KWSQTNLTYRIVNYT-PDMSHSEV 135

  Fly   165 ERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDA 229
            |:..:.|..||::.:.|.|..:|...|||.|.|..:.|||.|.||||..:|||||.||...||||
Mouse   136 EKAFRKAFKVWSDVTPLNFTRIYDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDA 200

  Fly   230 HFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGN----LPD 290
            |||.||||     :..|.|.|...||.|||||||||.||..|.|:|||.|   ...|.    |||
Mouse   201 HFDDDETW-----TSSSKGYNLFIVAAHELGHSLGLDHSKDPGALMFPIY---TYTGKSHFMLPD 257

  Fly   291 DDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARE 355
            ||..|||.|||..::                                       :||
Mouse   258 DDVQGIQFLYGPGDE---------------------------------------DPN-------- 275

  Fly   356 RQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWE 420
                                                                             
Mouse   276 ----------------------------------------------------------------- 275

  Fly   421 RNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTAN 485
                                                                             
Mouse   276 ----------------------------------------------------------------- 275

  Fly   486 TTPRPTNKPYPTVHRQHHHHNKPRKPK-PDSC--MTYYDAISIIRGELFIFRGPYLWRIGTSGLY 547
                                  |:.|| |:.|  ....|||:.:|||..||:..:.||:
Mouse   276 ----------------------PKHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRL------ 312

  Fly   548 NGYPTEI-------RRHWSALPENLTKVDAVYENKQRQIVF-FIGREYYVFNSVMLAPGFPKPLA 604
              :|.::       :..|..||.:   |||.||:..|.::| |.||:::..|...:..|:|:.::
Mouse   313 --HPQQVEAELFLTKSFWPELPNH---VDAAYEHPSRDLMFIFRGRKFWALNGYDILEGYPRKIS 372

  Fly   605 SLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAFQ 668
            .||.|..:..:.|:..:.:..:|...|....|..||....::.||||.: ..:.|:|..:||.::
Mouse   373 DLGFPKEVKRLSAAVHFENTGKTLFFSENHVWSYDDVNQTMDKDYPRLIEEEFPGIGNKVDAVYE 437

  Fly   669 YLDGKTYFFKNLGYWEFN 686
             .:|..|||.....:|::
Mouse   438 -KNGYIYFFNGPIQFEYS 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	82/163 (50%)
		ZnMc_MMP	143..301	CDD:239805	82/163 (50%)
		HX	513..707	CDD:238046	51/185 (28%)
Mmp13	NP_032633.1	PG_binding_1	33..92	CDD:279773	19/64 (30%)
		Cysteine switch. /evidence=ECO:0000250	95..102		6/21 (29%)
		Peptidase_M10	113..268	CDD:278824	82/163 (50%)
		ZnMc_MMP	113..268	CDD:239805	82/163 (50%)
		Interaction with TIMP2. /evidence=ECO:0000250	177..247		45/77 (58%)
		Interaction with collagen. /evidence=ECO:0000250	269..472		56/397 (14%)
		HX	282..472	CDD:238046	51/185 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920