Protein Alignment Mmp2 and Mmp11

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001293113.1
• Gene: Mmp11 / 17385
• MGIID: 97008
• Length: 492
• Species: Mus musculus
• Alignment Length: 614
• Identity: 181/614 - (29%)
• Similarity: 232/614 - (37%)
• Gaps: 215/614 - (35%)

  Fly   107 RCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLT-------WSMVNRSMPDASKV 164
            ||||.|       .||.|    .:..|.:||.|.|.:|.:||||       |.:|.      .:|
Mouse    83 RCGVPD-------LPDVL----NARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVR------EQV 130

  Fly   165 ERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDA 229
            .:.|..||.||:..:.|||.||:..:|||.|.|||..|||...|||||.:|||||:|...|.||.
Mouse   131 RQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDV 195

  Fly   230 HFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRY 294
            |||.||||..    .|:.||:.|.||.||.||.|||.|:....|:|.|:| ......:|..|||.
Mouse   196 HFDYDETWTI----GDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFY-TFRYPLSLSPDDRR 255

  Fly   295 GIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEE 359
            |||.|||         :||...|:...|.                   |:....|.|..
Mouse   256 GIQHLYG---------RPQMAPTSPAPTL-------------------SSQAGTDTNEI------ 286

  Fly   360 ERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPS 424
                                                                             
Mouse   287 ----------------------------------------------------------------- 286

  Fly   425 KERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPR 489
                                                              ...||.||
Mouse   287 --------------------------------------------------ALLEPETP------- 294

  Fly   490 PTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEI 554
                                   ||.|.|.:||:|.||||||.|:..::||:.:..|..|||...
Mouse   295 -----------------------PDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALA 336

  Fly   555 RRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASF 619
            .|||..||   :.|||.:|:.|.||.||.|.:|:|::......| |.||:.|||..:..|  |:.
Mouse   337 SRHWQGLP---SPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLG-PAPLSKLGLQGSPVH--AAL 395

  Fly   620 VWG-HNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYW 683
            ||| ..|:.|...|..|||....|.:|:...||..:.|.||...||||||..:|..||.:...||
Mouse   396 VWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYW 460

  Fly   684 EFNDDRMKVAHARAKLSARRWMQCARSAN 712
            :|:..::||.....:.....:..||..||
Mouse   461 KFDPVKVKVLEGFPRPVGPDFFDCAEPAN 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	75/164 (46%)
		ZnMc_MMP	143..301	CDD:239805	75/164 (46%)
		HX	513..707	CDD:238046	76/194 (39%)
Mmp11	NP_001293113.1	Cysteine switch. /evidence=ECO:0000250	82..89		5/12 (42%)
		Peptidase_M10	108..262	CDD:278824	75/164 (46%)
		ZnMc_MMP	108..262	CDD:239805	75/164 (46%)
		HX	295..484	CDD:238046	76/194 (39%)
		Hemopexin 1	295..343		23/47 (49%)
		Hemopexin 2	344..386		18/45 (40%)
		Hemopexin 3	388..436		16/49 (33%)
		Hemopexin 4	437..484		14/46 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880