DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and Mmp10

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_062344.1 Gene:Mmp10 / 17384 MGIID:97007 Length:476 Species:Mus musculus


Alignment Length:716 Identity:173/716 - (24%)
Similarity:257/716 - (35%) Gaps:263/716 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            :|||.:..:|   .:.|..|    |.|:...     |.|:...||.::....|::.:....:...
Mouse     6 ILALLSLPIC---SAYPLHG----AVTQGHP-----SMDLAQQYLEKYYNFKKNEKQIFKRKDSS 58

  Fly    75 QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFAL 139
            .:.:.|:.:|.|..:.:||::||.|..|:.||||||.|.....:|.        ||         
Mouse    59 PVVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFP--------GS--------- 106

  Fly   140 QGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAH 202
              |||.::.:|:.:||.: ||..:  |:..::.||.||...:.|||..:...:|||.|.||...|
Mouse   107 --PKWRKSHITYRIVNYT-PDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEH 168

  Fly   203 GDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAH 267
            ||.|.||||||.||||:.||.|..||.|||.||.|..     ...|||...||.|||||||||.|
Mouse   169 GDFYPFDGPGQSLAHAYPPGPGFYGDVHFDDDEKWTL-----APSGTNLFLVAAHELGHSLGLFH 228

  Fly   268 SAIPDAVMFPWYQNNEVAGN--LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYR 330
            |...:::|:|.|:.:....|  |..||..|||.|||.                            
Mouse   229 SDKKESLMYPVYRFSTSPANFHLSQDDIEGIQSLYGA---------------------------- 265

  Fly   331 ADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEE 395
                          .|::|..                                            
Mouse   266 --------------GPSSDAT-------------------------------------------- 272

  Fly   396 RWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRER 460
                                                                             
Mouse   273 ----------------------------------------------------------------- 272

  Fly   461 ERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSC--MTYYDAI 523
                               |.|..:.:|||..                    ||.|  ...:|::
Mouse   273 -------------------VVPVLSVSPRPET--------------------PDKCDPALSFDSV 298

  Fly   524 SIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPE-NL---------TKVDAVYE-NKQR 577
            |.:|||:..|:..|.||              |.||:..|| :|         :.:||.|| :...
Mouse   299 STLRGEVLFFKDRYFWR--------------RSHWNPEPEFHLISAFWPTLPSDLDAAYEAHNTD 349

  Fly   578 QIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYT 642
            .::.|.|.:::......:..|:||.:.:||.|||:..|||:.......:||...|..|||.|:..
Mouse   350 SVLIFKGSQFWAVRGNEVQAGYPKGIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETR 414

  Fly   643 GQVELDYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQ 706
            ..::..:||.:: .:.|:...:||..... |..|||:....:||:.:...|.|.   |.:..|:.
Mouse   415 HVMDKGFPRQITDDFPGIEPQVDAVLHEF-GFFYFFRGSSQFEFDPNARTVTHI---LKSNSWLL 475

  Fly   707 C 707
            |
Mouse   476 C 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 73/161 (45%)
ZnMc_MMP 143..301 CDD:239805 73/161 (45%)
HX 513..707 CDD:238046 57/207 (28%)
Mmp10NP_062344.1 PG_binding_1 28..87 CDD:279773 13/63 (21%)
Cysteine switch. /evidence=ECO:0000250 90..97 5/6 (83%)
Peptidase_M10 108..264 CDD:278824 73/161 (45%)
ZnMc_MMP 108..264 CDD:239805 73/161 (45%)
HX 286..476 CDD:238046 57/207 (28%)
Hemopexin 1 286..335 18/62 (29%)
Hemopexin 2 336..382 11/45 (24%)
Hemopexin 3 384..432 12/47 (26%)
Hemopexin 4 433..476 12/46 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X44
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.920

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