DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp12

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_032631.3	Gene:	Mmp12 / 17381	MGIID:	97005	Length:	473	Species:	Mus musculus

Alignment Length:	666	Identity:	154/666 - (23%)
Similarity:	236/666 - (35%)	Gaps:	243/666 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLMQF-----DYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGD 112
            ||.:|     |.:|.:..:|    ..:.|||.::.:|.|..:..||::|::|..::..|||||.|
Mouse    40 YLSRFYDYGKDRIPMTKTKT----NRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPD 100

  Fly   113 RRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVW 175
                               |:..|...|..:|.:..||:.:.|.: ||..:  |:.:.|.|..||
Mouse   101 -------------------VQHLRAVPQRSRWMKRYLTYRIYNYT-PDMKREDVDYIFQKAFQVW 145

  Fly   176 ANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFD 240
            ::.:.|.||:::.|:|||.||||..||||...|||.|..||||||||.|..||||||..|||
Mouse   146 SDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETW--- 207

  Fly   241 GESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN-NEVAGNLPDDDRYGIQQLYGTKE 304
              :....|||...||:|||||||||.||..|.::|:|.|:. |.....|..||...||.|||
Mouse   208 --TKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYG--- 267

  Fly   305 KTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERR 369
               .|.||.:.|
Mouse   268 ---APVKPPSLT----------------------------------------------------- 276

  Fly   370 RQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQ 434

Mouse   277 ----------------------------------------------------------------- 276

  Fly   435 EMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVH 499
                                                                  :|::.|....|
Mouse   277 ------------------------------------------------------KPSSPPSTFCH 287

  Fly   500 RQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYL-WRIGTSGLYNGYPTEIRRHWSALPE 563
            :.                ..:||::.:..::|.|:..:. |::..|...|  .|.|...|.::|.
Mouse   288 QS----------------LSFDAVTTVGEKIFFFKDWFFWWKLPGSPATN--ITSISSIWPSIPS 334

  Fly   564 NLTKVDAVYENKQR-QIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRT 627
            .   :.|.||.:.| |:..|...:|::.|:::..|.:|:.:.|||...::..:||:.......:.
Mouse   335 G---IQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKV 396

  Fly   628 YMTSGTLYWRIDDYTGQVELDYPRDMSI-WSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMK 691
            |......|||.|.....::..||:.:|. :.|:...|||.. |.....|.|:.....|::....:
Mouse   397 YFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVL-YFKRHYYIFQGAYQLEYDPLFRR 460

  Fly   692 VAHARAKLSARRWMQC 707
            |...   |.:..|..|
Mouse   461 VTKT---LKSTSWFGC 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	75/160 (47%)
		ZnMc_MMP	143..301	CDD:239805	75/160 (47%)
		HX	513..707	CDD:238046	45/196 (23%)
Mmp12	NP_032631.3	PG_binding_1	31..91	CDD:279773	15/54 (28%)
		Cysteine switch. /evidence=ECO:0000250	94..101		6/25 (24%)
		Peptidase_M10	112..267	CDD:278824	75/160 (47%)
		ZnMc_MMP	112..267	CDD:239805	75/160 (47%)
		HX	289..473	CDD:238046	45/208 (22%)
		Hemopexin 1	289..332		10/60 (17%)
		Hemopexin 2	333..379		14/48 (29%)
		Hemopexin 3	381..429		10/47 (21%)
		Hemopexin 4	430..473		10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920