Protein Alignment Mmp2 and Mmp13

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_598214.1
• Gene: Mmp13 / 171052
• RGDID: 620196
• Length: 472
• Species: Rattus norvegicus
• Alignment Length: 668
• Identity: 170/668 - (25%)
• Similarity: 247/668 - (36%)
• Gaps: 276/668 - (41%)

  Fly    47 EDIMY--NYLMQFDY-------LPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARL 102
            ||:.:  :||..:.:       |.||.:.:    |.|:|:|    :|||..:.|||::|..|..:
  Rat    35 EDLEFAEHYLKSYYHPVTLAGILKKSTVTS----TVDRLRE----MQSFFGLDVTGKLDDPTLDI 91

  Fly   103 IQKPRCGVGDRRSADSFSPDNLYHEIGS-NVRVRRFALQGPKWSRTDLTWSMVNRSMPDA--SKV 164
            ::||||||.|               :|. ||..|..     |||:|:||:.:||.: ||.  |:|
  Rat    92 MRKPRCGVPD---------------VGEYNVFPRTL-----KWSQTNLTYRIVNYT-PDISHSEV 135

  Fly   165 ERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDA 229
            |:..:.|..||::.:.|.|..::...|||.|.|..:.|||.|.||||..:|||||.||...||||
  Rat   136 EKAFRKAFKVWSDVTPLNFTRIHDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNLGGDA 200

  Fly   230 HFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGN----LPD 290
            |||.||||     :..|.|.|...||.|||||||||.||..|.|:|||.|   ...|.    |||
  Rat   201 HFDDDETW-----TSSSKGYNLFIVAAHELGHSLGLDHSKDPGALMFPIY---TYTGKSHFMLPD 257

  Fly   291 DDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARE 355
            ||..|||.|||..::                                       :||
  Rat   258 DDVQGIQSLYGPGDE---------------------------------------DPN-------- 275

  Fly   356 RQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWE 420
                                                                             
  Rat   276 ----------------------------------------------------------------- 275

  Fly   421 RNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTAN 485
                                                                             
  Rat   276 ----------------------------------------------------------------- 275

  Fly   486 TTPRPTNKPYPTVHRQHHHHNKPRKPK-PDSC--MTYYDAISIIRGELFIFRGPYLWRIGTSGLY 547
                                  |:.|| |:.|  ....|||:.:|||..||:..:.||:
  Rat   276 ----------------------PKHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRL------ 312

  Fly   548 NGYPTEI-------RRHWSALPENLTKVDAVYENKQRQIVF-FIGREYYVFNSVMLAPGFPKPLA 604
              :|.::       :..|..||.:   |||.||:..|.::| |.||:::..|...:..|:|:.::
  Rat   313 --HPQQVEPELFLTKSFWPELPNH---VDAAYEHPSRDLMFIFRGRKFWALNGYDIMEGYPRKIS 372

  Fly   605 SLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAFQ 668
            .||.|..:..:.|:..:....:|...||...|..||....::.||||.: ..:.|:|..:||.::
  Rat   373 DLGFPKEVKRLSAAVHFEDTGKTLFFSGNHVWSYDDANQTMDKDYPRLIEEEFPGIGDKVDAVYE 437

  Fly   669 YLDGKTYFFKNLGYWEFN 686
             .:|..|||.....:|::
  Rat   438 -KNGYIYFFNGPIQFEYS 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	81/163 (50%)
		ZnMc_MMP	143..301	CDD:239805	81/163 (50%)
		HX	513..707	CDD:238046	52/185 (28%)
Mmp13	NP_598214.1	PG_binding_1	40..92	CDD:396175	17/59 (29%)
		Peptidase_M10	113..268	CDD:395334	81/163 (50%)
		HX	282..472	CDD:238046	52/185 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920