DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp3

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_598207.2	Gene:	Mmp3 / 171045	RGDID:	621317	Length:	475	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	174/694 - (25%)
Similarity:	250/694 - (36%)	Gaps:	245/694 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGN 88
            |.|..||...|..           :::..||..:..|.|...:....:....:.:.|:.:|.|..
  Rat    17 SYPLHGSEEDAGM-----------EVLQKYLENYYGLEKDVKQFTKKKDSSPVVKKIQEMQKFLG 70

  Fly    89 ITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSM 153
            :.:||::||.|..|:.||||||.|.....:|.        ||           |||.:..:::.:
  Rat    71 LKMTGKLDSNTMELMHKPRCGVPDVGGFSTFP--------GS-----------PKWRKNHISYRI 116

  Fly   154 VNRS--MPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLA 216
            ||.:  :|..| |:..::.||.||...:.|||..:...:|||.|.||...|||...|||||.|||
  Rat   117 VNYTLDLPRES-VDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVEEHGDFIPFDGPGMVLA 180

  Fly   217 HAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN 281
            ||:.||.|..||||||.||.|     :||..|||...||.|||||||||.|||..:|:|:|.|::
  Rat   181 HAYAPGPGINGDAHFDDDERW-----TDDVTGTNLFLVAAHELGHSLGLFHSANAEALMYPVYKS 240

  Fly   282 N-EVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSN 344
            : ::|. :|..||..|||.|||.                                       |:.
  Rat   241 STDLARFHLSQDDVDGIQSLYGP---------------------------------------PTE 266

  Fly   345 NPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENR 409
            :|:
  Rat   267 SPD-------------------------------------------------------------- 269

  Fly   410 RRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRN 474

  Rat   270 ----------------------------------------------------------------- 269

  Fly   475 GAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLW 539
               ..|.||.:.:..|...|.                  .|....:||:|.:|||:..|:..:.|
  Rat   270 ---VLVVPTKSNSLDPETLPM------------------CSSALSFDAVSTLRGEVLFFKDRHFW 313

  Fly   540 ----RIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFI-GREYYVFNSVMLAPGF 599
                |....|.|     .|...|.:||.|:   ||.||...|..||.: |.:.:.........|:
  Rat   314 RKSLRTPEPGFY-----LISSFWPSLPSNM---DAAYEVTNRDTVFILKGNQIWAIRGHEELAGY 370

  Fly   600 PKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMS-IWSGVGYNI 663
            ||.:.:||||.|:..|||:.......:||......:||.|:....::..:||.:: .:.|:|..:
  Rat   371 PKSIHTLGLPETVQKIDAAISLKDQKKTYFFVEDKFWRFDEKKQSMDPGFPRKIAENFPGIGTKV 435

  Fly   664 DAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            ||.|:.. |..|||......||:.:..||.|.   |.:..|..|
  Rat   436 DAVFEAF-GFLYFFSGSSQLEFDPNAGKVTHI---LKSNSWFNC 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	76/161 (47%)
		ZnMc_MMP	143..301	CDD:239805	76/161 (47%)
		HX	513..707	CDD:238046	59/199 (30%)
Mmp3	NP_598207.2	PG_binding_1	25..85	CDD:396175	13/70 (19%)
		Cysteine switch. /evidence=ECO:0000269\|PubMed:1988438, ECO:0000269\|PubMed:2841336	88..95		5/6 (83%)
		Peptidase_M10	106..262	CDD:395334	76/161 (47%)
		Hemopexin 1	285..334		15/71 (21%)
		HX	288..475	CDD:238046	59/198 (30%)
		Hemopexin 2	335..381		16/48 (33%)
		Hemopexin 3	383..431		10/47 (21%)
		Hemopexin 4	432..475		15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020