Protein Alignment Mmp2 and Mmp1

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_308849.4
• Gene: Mmp1 / 1270173
• VectorBaseID: AGAMI1_001178
• Length: 568
• Species: Anopheles gambiae
• Alignment Length: 684
• Identity: 188/684 - (27%)
• Similarity: 259/684 - (37%)
• Gaps: 221/684 - (32%)

  Fly    34 AATRSKKAKTAISEDIMYNYLMQFDYL-PK-SDLETGALRTEDQLKEAIRSLQSFGNITVTGEID 96
            |.|.|..:.|..:|    .||.||.|| || .:..:|.|..:|..::||...|||..:.||||:|
Mosquito    22 AGTASPVSTTPQAE----LYLSQFGYLSPKYRNPTSGNLLDQDTWEKAIMEFQSFAGLNVTGELD 82

  Fly    97 SATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTW--SMVNRSMP 159
            ..|.:|:..|||||.|:..            .||:.|.:|:||||.:|...|||:  |...|.:
Mosquito    83 GETMQLMSLPRCGVKDKVG------------FGSDTRSKRYALQGSRWKVKDLTYRISKYPRRL- 134

  Fly   160 DASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEG 224
            :.:.|::.:..|..||:.::.|.|....:....|.|.|....||||..|||||..||||::|  .
Mosquito   135 ERTAVDKEIAKAFGVWSEYTDLRFTPKKTGAVHIDIRFEENEHGDGDPFDGPGGTLAHAYFP--V 197

  Fly   225 RGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLP 289
            .|||||||..|.|..    |...|||...||.||.||||||:||.:..|:|.|:|:..:....|.
Mosquito   198 YGGDAHFDDAEQWTI----DKPRGTNLFQVAAHEFGHSLGLSHSDVRSALMAPFYRGYDPVFRLD 258

  Fly   290 DDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRAR 354
            .||..|||.|||||
Mosquito   259 SDDIQGIQTLYGTK--------------------------------------------------- 272

  Fly   355 ERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQW 419
                                                                             
Mosquito   273 ----------------------------------------------------------------- 272

  Fly   420 ERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTA 484
            .|||                                                   |.....|||
Mosquito   273 TRNP---------------------------------------------------GGGAGATPT- 285

  Fly   485 NTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNG 549
             .||||..   ||    .........||.|:.....|      |..:.|:|...:::..:.:..|
Mosquito   286 -RTPRPKT---PT----EMDSELCTSPKIDAIFNTAD------GSTYAFKGDKYYKLTENAVAEG 336

  Fly   550 YPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLAS--LGLPPTL 612
            ||.:|...|..||.|   :||.:..|..:..||.|.:|:.:....:...:||.::.  .|:|
Mosquito   337 YPKKISDGWPGLPGN---IDAAFTYKNGKTYFFQGTKYWRYQGRTIDGDYPKEISEGFTGVP--- 395

  Fly   613 THIDASFVWGHNNRTYMTSGTLYWRIDDY-TGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYF 676
            .|:||:.|||.|.:.|...|:.:||.|.. ...|:..||:.:|.|.||..::|||.||.:|.|||
Mosquito   396 DHLDAAMVWGGNGKIYFYKGSKFWRFDPLKRPPVKSTYPKPISNWEGVPNSVDAALQYTNGYTYF 460

  Fly   677 FKNLGYWEFNDDRMKVAHAR---AKLSARRWMQC 707
            ||:..|:.|||....|..:.   .:.:|..|..|
Mosquito   461 FKDDKYYRFNDRTFTVDQSDPPFPRPTAHWWYGC 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	22/52 (42%)
		Peptidase_M10	143..301	CDD:425668	65/159 (41%)
		HX	513..707	CDD:238046	61/199 (31%)
Mmp1	XP_308849.4	None