DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and MMP21

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_671724.1 Gene:MMP21 / 118856 HGNCID:14357 Length:569 Species:Homo sapiens


Alignment Length:699 Identity:144/699 - (20%)
Similarity:219/699 - (31%) Gaps:304/699 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 PKSDLET--GALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDN 123
            |:...||  ||     .|.||:|..|....:..:||:|:||...:.:|||||.|.|.....:|.:
Human    73 PEGPPETPKGA-----ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPS 132

  Fly   124 LYHEIGSNVRVRR-------FALQGPKW--------------SRTDLTWSMVNRSMPDASKV--- 164
               ..|...|.|.       .:|....|              |:..|:|.::..::.....|   
Human   133 ---PPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQ 194

  Fly   165 ERMVQTALDVWANHSKLTFREVYSDQA------DIQILFARRAH-GDGYKFDGPGQVLAHAFYPG 222
            .|:|..|..:|:..:.|.|||   |.|      ||::.|.|..| |....|||.||..|||:   
Human   195 RRIVALAFRMWSEVTPLDFRE---DLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAW--- 253

  Fly   223 EGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGN 287
              |.||.|||.||  :|...:.|: |.:.|.||:||:||.|||.|:....::|.|.|...|.|..
Human   254 --RLGDIHFDDDE--HFTPPTSDT-GISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFE 313

  Fly   288 LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNR 352
            |...||..||:|||:.|.::                                             
Human   314 LDWSDRKAIQKLYGSCEGSF--------------------------------------------- 333

  Fly   353 ARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKS 417
                                                                             
Human   334 ----------------------------------------------------------------- 333

  Fly   418 QWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTP 482
                                                         |...:|.|:.||        
Human   334 ---------------------------------------------DTAFDWIRKERN-------- 345

  Fly   483 TANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLY 547
                                                .|..: ::|...:.||..:.|      ||
Human   346 ------------------------------------QYGEV-MVRFSTYFFRNSWYW------LY 367

  Fly   548 N--------GYPTEIRRHWSALPENLTKVDA---VYENKQRQIVFFIGREYYVFNS--------- 592
            .        |.|.:|...|..:|.:  .:||   ::..|:.:..||.|.:|:.::|         
Human   368 ENRNNRTRYGDPIQILTGWPGIPTH--NIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTED 430

  Fly   593 -------VMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYP 650
                   .:::.|||      |:|..|   |.:|........|....:|.:..|....:|...||
Human   431 EQGKSYPKLISEGFP------GIPSPL---DTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYP 486

  Fly   651 RDMS-IWSGV------GYNIDAA-FQYLDGKTYFFKNLGYWEFNDDRMK 691
            :.:: ::..|      ..|||:| :.|.....:|||...||:..:|:.|
Human   487 KRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDK 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 62/181 (34%)
ZnMc_MMP 143..301 CDD:239805 62/181 (34%)
HX 513..707 CDD:238046 47/214 (22%)
MMP21NP_671724.1 PG_binding_1 48..112 CDD:279773 15/43 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..166 13/53 (25%)
Cysteine switch. /evidence=ECO:0000250 115..122 5/6 (83%)
Peptidase_M10 170..327 CDD:278824 61/167 (37%)
ZnMc_MMP 171..327 CDD:239805 61/166 (37%)
Hemopexin 1 330..389 17/264 (6%)
HX 350..536 CDD:238046 46/204 (23%)
Hemopexin 2 391..447 11/63 (17%)
Hemopexin 3 448..496 10/50 (20%)
Hemopexin 4 503..559 12/33 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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