Protein Alignment Mmp2 and Mmp28

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001307229.1
• Gene: Mmp28 / 118453
• MGIID: 2153062
• Length: 520
• Species: Mus musculus
• Alignment Length: 683
• Identity: 156/683 - (22%)
• Similarity: 241/683 - (35%)
• Gaps: 219/683 - (32%)

  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|.::.||.:...:..|   ..|.:.|||..|....:.::|.:|.||.|.:.:|||||.|..|..
Mouse    39 FLEKYGYLSEQGSKAPA---SAQFRNAIREFQWISQLPLSGVLDQATLRQMTRPRCGVADTDSHA 100

  Fly   118 SFSPDNLYHEIGSNVRVR---RFALQGPKWSRTDLTWSMVN--RSMPDASKVERMVQTALDVWAN 177
            :::........|...::|   |||..|.||.:..|::.:||  ..:|:.: |...|:.|..:|:|
Mouse   101 TWTERISTLLAGHRAKMRRKKRFAKPGNKWYKQHLSYRLVNWPERLPEPA-VRGAVRAAFQLWSN 164

  Fly   178 HSKLTFREV-YSDQADIQILFARRAHGDGY--KFDGPGQVLAHAFYPGEGRGGDAHFDADETWNF 239
            .|.|.|.|. .:..|||::.|.:..|.||.  .|||||..|||||.|   |.|:||||.||.|:.
Mouse   165 VSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLP---RRGEAHFDGDERWSL 226

  Fly   240 DGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKE 304
            ...    .|.|...|..||:||:|||.||..|.|:|.|:|:.......|..||...:|.|||
Mouse   227 SRR----RGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDVLAVQSLYG--- 284

  Fly   305 KTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERR 369
                  ||...:..|
Mouse   285 ------KPLGRSVAT-------------------------------------------------- 293

  Fly   370 RQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQ 434
                           |:..:...:.|.|
Mouse   294 ---------------QLPGKVFTDFEAW------------------------------------- 306

  Fly   435 EMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVH 499
                                                       :|
Mouse   307 -------------------------------------------DP-------------------- 308

  Fly   500 RQHHHHNKPRKPK---PDSCMTYYDAISII-RGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
                |:::.|:|:   |..|.:.:|||::. :..|::|:|.|.|.:...|..: .|..:::.|..
Mouse   309 ----HNSQSRRPETRGPKYCHSSFDAITVDGQWRLYVFKGSYFWEVTVDGNVS-EPRPLQKRWPG 368

  Fly   561 LPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNN 625
            ||..:..  |....:.....||.|...:.|.......||.:...:.|||   .|.||:..:....
Mouse   369 LPPGIEA--AAVSLEDGDFYFFKGNRCWRFQGTKSVWGFAQLCRAGGLP---RHPDAALFFPPLR 428

  Fly   626 RTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRM 690
            |..:..|:.|:.:.....|||..|||.:..|:||...:..|....||...||::..||..:..::
Mouse   429 RLVLFKGSRYYVLAQGGMQVEPYYPRSLRDWAGVPEEVSGALPRPDGSIIFFRDDHYWHLDQAKL 493

  Fly   691 KVAHARAKLSARRWMQCARSANEVDDEQRWTAS 723
            :|..:....:...||.|            |.|:
Mouse   494 RVTSSGRWATELSWMGC------------WNAN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	14/49 (29%)
		Peptidase_M10	143..301	CDD:425668	64/162 (40%)
		HX	513..707	CDD:238046	50/194 (26%)
Mmp28	NP_001307229.1	PG_binding_1	31..86	CDD:460223	14/49 (29%)
		ZnMc_MMP	129..284	CDD:239805	64/162 (40%)
		HX	321..510	CDD:238046	50/194 (26%)