DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp2 and Mmp10

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_598198.2	Gene:	Mmp10 / 117061	RGDID:	620192	Length:	476	Species:	Rattus norvegicus

Alignment Length:	711	Identity:	174/711 - (24%)
Similarity:	261/711 - (36%)	Gaps:	253/711 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALFAQSMCIQELSLPPEGS----HSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGAL 70
            :|.|....:|   .:.|..|:    |||.             |:...||.::....|::.:....
  Rat     6 ILVLLCFPIC---SAYPLHGAVRQDHSTM-------------DLAQQYLEKYYNFRKNEKQFFKR 54

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
            :....:.:.|..:|.|..:.:||::||.|..::.||||||.|.....:|.        ||
  Rat    55 KDSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPDVGGFSTFP--------GS----- 106

  Fly   136 RFALQGPKWSRTDLTWSMVNRS--MPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFA 198
                  |||.:..:::.:||.:  :|..| |:..::.||.||...:.|||..:...:|||.|.||
  Rat   107 ------PKWRKNHISYRIVNYTLDLPRES-VDSAIERALKVWEEVTPLTFSRISEGEADIMISFA 164

  Fly   199 RRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSL 263
            ...|||.|.|||.||.||||:.||.|..||||||.||.|:. |.|    |||...||.|||||||
  Rat   165 VGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSL-GPS----GTNLFLVAAHELGHSL 224

  Fly   264 GLAHSAIPDAVMFPWYQNNEVAGN--LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRA 326
            ||.||...:::|:|.|:.:....|  |..||..|||.|||.:
  Rat   225 GLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGAR----------------------- 266

  Fly   327 MIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQR 391
                               |::|
  Rat   267 -------------------PSSD------------------------------------------ 270

  Fly   392 QEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDR 456

  Rat   271 ----------------------------------------------------------------- 270

  Fly   457 RRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKP-KPDSCMTYY 520
                                       |...|.|:..|            ||..| |.|..:: :
  Rat   271 ---------------------------ATVVPVPSVSP------------KPETPVKCDPALS-F 295

  Fly   521 DAISIIRGELFIFRGPYLWRIGTSGLYNGYPT--EIRRHWSALPENLTKVDAVYE-NKQRQIVFF 582
            ||::::|||...|:..:.||   ...:|..|.  .|...|.:||..|   ||.|| |.:.:::.|
  Rat   296 DAVTMLRGEFLFFKDRHFWR---RTQWNPEPEFHLISAFWPSLPSGL---DAAYEANNKDRVLIF 354

  Fly   583 IGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVEL 647
            .|.:::......:..|:||.:.:||.|||:..|||:.......:||...|..|||.|:....::.
  Rat   355 KGSQFWAVRGNEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRQLMDK 419

  Fly   648 DYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            .:||.:: .:.|:...:||.. :..|..|||:....:||:.:...|.|.   |.:..|:.|
  Rat   420 GFPRLITDDFPGIEPQVDAVL-HAFGFFYFFRGSSQFEFDPNARTVTHT---LKSNSWLLC 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	74/161 (46%)
		ZnMc_MMP	143..301	CDD:239805	74/161 (46%)
		HX	513..707	CDD:238046	56/197 (28%)
Mmp10	NP_598198.2	PG_binding_1	33..87	CDD:396175	11/53 (21%)
		Cysteine switch. /evidence=ECO:0000250	90..97		5/6 (83%)
		Peptidase_M10	108..264	CDD:395334	74/161 (46%)
		HX	286..476	CDD:238046	58/200 (29%)
		Hemopexin 1	286..335		15/52 (29%)
		Hemopexin 2	336..382		14/48 (29%)
		Hemopexin 3	384..432		12/47 (26%)
		Hemopexin 4	433..476		12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920