Protein Alignment Mmp2 and Mmp12

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_446415.2
• Gene: Mmp12 / 117033
• RGDID: 620195
• Length: 477
• Species: Rattus norvegicus
• Alignment Length: 668
• Identity: 157/668 - (23%)
• Similarity: 239/668 - (35%)
• Gaps: 247/668 - (36%)

  Fly    53 YLMQF-----DYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGD 112
            ||.:|     |.:|.:..:|    ..:.|:|.::.:|.|..:.|||::|::|.:::...||||.|
  Rat    44 YLSRFFDYQGDRIPMTKTKT----NRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPD 104

  Fly   113 RRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVW 175
                               |:..|...|..:|.:..||:.:.|.: ||..:  |:.:.|.|..||
  Rat   105 -------------------VQHLRAVPQRSRWMKRYLTYRIYNYT-PDMKRADVDYIFQKAFQVW 149

  Fly   176 ANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFD 240
            ::.:.|.||:::..:|||.||||...|||.|.|||.|..||||||||.|..||||||..|||
  Rat   150 SDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQGDAHFDEAETW--- 211

  Fly   241 GESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN-NEVAGNLPDDDRYGIQQLYGTKE 304
              :....|||...||:|||||||||.||..|.::|:|.|:. :.....|..||.:.||.|||.
  Rat   212 --TKSFQGTNLFLVAVHELGHSLGLPHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYGA-- 272

  Fly   305 KTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPS-NNPNNDRNRARERQEEERRRQEKER 368
                                             |..||| .||.:
  Rat   273 ---------------------------------PVKNPSLTNPGS-------------------- 284

  Fly   369 RRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRER 433
                                                                             
  Rat   285 ----------------------------------------------------------------- 284

  Fly   434 QEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTV 498
                                                                        |..||
  Rat   285 ------------------------------------------------------------PPSTV 289

  Fly   499 HRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYL-WRIGTSGLYNGYPTEIRRHWSALP 562
            ..|               ...:||::.:..::|.|:..:. ||:..|...|  .|.|...|..:|
  Rat   290 CHQ---------------SLSFDAVTTVGDKIFFFKDWFFWWRLPGSPATN--ITSISSMWPTIP 337

  Fly   563 ENLTKVDAVYE-NKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNR 626
            ..   :.|.|| ..:.|:..|...:|::.|:::..|.:|:.:.|||.|.::..|||:.......:
  Rat   338 SG---IQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHYPRSIHSLGFPASVKKIDAAVFDPLRQK 399

  Fly   627 TYMTSGTLYWRIDDYTGQVELDYPRDMSI-WSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRM 690
            .|......|||.|.....::..||:.:|. :.|:...|||...:   |.:::...|.::...|
  Rat   400 VYFFVDKQYWRYDVRQELMDAAYPKLISTHFPGIRPKIDAVLYF---KRHYYIFQGAYQLEYD-- 459

  Fly   691 KVAHARAK-LSARRWMQC 707
            .:.|...| ||:..|..|
  Rat   460 PLLHRVTKTLSSTSWFGC 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	73/160 (46%)
		ZnMc_MMP	143..301	CDD:239805	73/160 (46%)
		HX	513..707	CDD:238046	48/197 (24%)
Mmp12	NP_446415.2	PG_binding_1	41..95	CDD:279773	15/54 (28%)
		Peptidase_M10	116..271	CDD:278824	73/160 (46%)
		ZnMc_MMP	116..271	CDD:239805	73/160 (46%)
		HX	293..477	CDD:238046	48/193 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920