Protein Alignment Mmp2 and mmp24

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_031750429.1
• Gene: mmp24 / 100492405
• XenbaseID: XB-GENE-1009940
• Length: 633
• Species: Xenopus tropicalis
• Alignment Length: 734
• Identity: 203/734 - (27%)
• Similarity: 301/734 - (41%)
• Gaps: 212/734 - (28%)

  Fly    13 LFAQSMCIQELSLPP----------EGSHSTAATRSK---KAKTAISEDIMY--NYLMQFDYLPK 62
            |.|.|....||.||.          :.|..|:|..|:   ::.|:|::...:  .:|..:.||..
 Frog    17 LAAASWLASELQLPATELPFSAAELQLSAVTSAWSSRVFARSGTSITDGTPHVPRWLKTYGYLLP 81

  Fly    63 SDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHE 127
            .|:...||::...::.|:.::|.|..|.||||:|..|...::||||||.|            :..
 Frog    82 YDIRISALQSGKAMQSAVSAMQQFYGIPVTGELDQMTIEWMKKPRCGVPD------------HPH 134

  Fly   128 IGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHSKLTFREV-YSD 189
            :....|.:|:||.|.||.:..:|:|:.|.: |...:::  :.::.|.|||...:.|||.|: ||:
 Frog   135 LSHRRRNKRYALTGQKWRQKHITYSIHNYT-PKVGELDTRKAIRQAFDVWQKVTPLTFEEIPYSE 198

  Fly   190 ------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHG 248
                  :|||.|.||...|||...|||.|..||||::||.|.|||.|||:||.|.....:.|  |
 Frog   199 IKNERKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNSNHD--G 261

  Fly   249 TNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKP 312
            .:...||:|||||:|||.||..|.|:|.|:||..|... .||.||..|||::||...:|..|.:|
 Frog   262 NDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAETMEPTRP 326

  Fly   313 QTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRH 377
            ..|.                                                       ...|.|
 Frog   327 LPTL-------------------------------------------------------PPRRIH 336

  Fly   378 QEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQE 442
            ...||:.                                   ||.|     ||
 Frog   337 STSERKH-----------------------------------ERQP-----RP------------ 349

  Fly   443 QERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPT--NKPYPTVHRQHHHH 505
                                                         |||.  :||..|..|
 Frog   350 ---------------------------------------------PRPPLGDKPPSTGSR----- 364

  Fly   506 NKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDA 570
                   |:.|...::.:::.|||:|:|:..:.||:..:.:..|||.:|.:.|..||   .|:||
 Frog   365 -------PNICDGNFNTVALFRGEMFVFKDRWFWRLRNNKVQEGYPMQIEQFWKGLP---PKIDA 419

  Fly   571 VYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLY 635
            .||....:.|||.|.:|:||..|...||:|..|..||.......||.:..|...::||...|..|
 Frog   420 AYERSDGKFVFFKGDKYWVFKEVTAEPGYPHSLVELGSCLPREGIDTALRWETFSKTYFFKGDRY 484

  Fly   636 WRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLGYWEFNDDRMKVAHARAKL 699
            ||.::.....:..||:.::||.|:..:...||...:|. |||:|...||:|::.|:.|.....:.
 Frog   485 WRYNEEKRAADPGYPKPITIWKGIPESPQGAFVSKEGSYTYFYKGREYWKFDNQRLTVEPGYPRS 549

  Fly   700 SARRWMQCARSANEVDDEQ 718
            ..:.||.|  :..|||:.:
 Frog   550 IVKDWMGC--NQKEVDNSK 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	16/50 (32%)
		Peptidase_M10	143..301	CDD:425668	73/167 (44%)
		HX	513..707	CDD:238046	63/194 (32%)
mmp24	XP_031750429.1	PG_binding_1	71..122	CDD:460223	16/50 (32%)
		Peptidase_M10	150..315	CDD:425668	73/167 (44%)
		HX	365..557	CDD:238046	63/194 (32%)
		DUF3377	563..633	CDD:463374	1/4 (25%)