DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp15b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_021323108.1	Gene:	mmp15b / 100332426	ZFINID:	ZDB-GENE-070817-6	Length:	655	Species:	Danio rerio

Alignment Length:	687	Identity:	188/687 - (27%)
Similarity:	274/687 - (39%)	Gaps:	192/687 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSA 116
            ::|..:.|||::..:...:|:...|..||..:|.|..:.:|||:|..|...:::|||||
Zfish    41 SWLRMYGYLPQASRQMSTMRSAQILSNAISDMQRFYGLEITGEMDPGTIEAMKRPRCGV------ 99

  Fly   117 DSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHS 179
                ||....:|.:|||.:|:||.|.||.:|.:|:|:.|.: |...:..  ..::.|..||...:
Zfish   100 ----PDKFGAQIKTNVRRKRYALTGHKWDKTHITFSIQNYT-PKIGEYNSYEAIRRAFRVWEKVT 159

  Fly   180 KLTFREV------YS--DQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADET 236
            .|||.|:      |.  .:.||.|.||...|||...|||.|..||||::||.|.|||.|||:||.
Zfish   160 PLTFDEIPFHEVKYGRRKEPDIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGMGGDTHFDSDEP 224

  Fly   237 WNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLY 300
            |...  |.:..|.:...||:|||||:|||.||..|.|:|.|:||..:... .||:||..|:||:|
Zfish   225 WTIG--SQNLQGNDLFLVAVHELGHALGLEHSNNPLAIMAPFYQWMDTENFELPEDDLRGVQQIY 287

  Fly   301 GTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQE 365
                   ||.....|....|.|..|        ||
Zfish   288 -------GPPSSSPTQALPTVTPRR--------PA------------------------------ 307

  Fly   366 KERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRP 430
                                                             |......||.|.
Zfish   308 -------------------------------------------------HPDPRAPNPPKS---- 319

  Fly   431 RERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPY 495
                                                           .|..|     ||..:||.
Zfish   320 -----------------------------------------------PPGAP-----PRRPDKPR 332

  Fly   496 PTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
            .|....|:        .|:.|...:|.::::|||:|:|:|.:.||:..:.:.:.||..|...|..
Zfish   333 TTDRPDHY--------GPNICEGNFDTVTMLRGEMFVFKGRWFWRVRRNRVLDNYPMPIGHFWRG 389

  Fly   561 LPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNN 625
            ||.:   :||.||....:.|||.|.:|::|....|..|:|:.|...|.......||.:..|..:.
Zfish   390 LPGD---IDAAYERHDGRFVFFKGSQYWLFREANLESGYPQELMDYGRDIPYDKIDTAIWWEPSG 451

  Fly   626 RTYMTSGTLYWRIDDYTGQVELDYPRDMSIW-SGVGYNIDAAFQYLDGK-TYFFKNLGYWEFNDD 688
            .||...|..|||.::.....:.|||:.:|:| :.|..:...||...||. |||:|...||:|::.
Zfish   452 FTYFFKGDWYWRFNEQDRAADQDYPKPISVWGTSVPSSPKGAFLSDDGAYTYFYKGAKYWKFDNH 516

  Fly   689 RMKVAHARAKLSARRWMQCARSAN-----EVDDEQRW 720
            ||.......|...|.:|.|....:     :||..::|
Zfish   517 RMTSEPGYPKSILRDFMGCNVDLDPDRDTDVDQGRKW 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	70/168 (42%)
		ZnMc_MMP	143..301	CDD:239805	70/168 (42%)
		HX	513..707	CDD:238046	63/195 (32%)
mmp15b	XP_021323108.1	PG_binding_1	40..92	CDD:307564	15/50 (30%)
		Peptidase_M10	122..288	CDD:306839	71/175 (41%)
		HX	342..535	CDD:238046	63/195 (32%)
		DUF3377	596..655	CDD:314687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950