DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp17b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001352431.1	Gene:	mmp17b / 100322027	ZFINID:	ZDB-GENE-081107-17	Length:	613	Species:	Danio rerio

Alignment Length:	740	Identity:	188/740 - (25%)
Similarity:	274/740 - (37%)	Gaps:	251/740 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TAI-SED---IMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLI 103
            ||| :||   .:.::|.::.|||..|..||.|:....:.:|::.:|||..:..||.:|..|.:|:
Zfish    44 TAIPTEDESGKLVDWLTKYGYLPPPDPSTGQLQAWTAVTQAVKKMQSFAGLDETGILDEETLQLM 108

  Fly   104 QKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVER-- 166
            |.|||.:.|....|. :..:..|....|.|::|..   ..|:|.::.|.:  ||.|.:||:.|
Zfish   109 QTPRCSLPDDDDDDQ-TIHSAQHADPQNQRMKRAV---STWTRRNINWRL--RSYPVSSKLSRET 167

  Fly   167 ---MVQTALDVWANHSKLTFREVYSDQ-ADIQILFARRAHGDGYKFDGPGQVLAHAFYPGE-GRG 226
               :|..||.|||:.:.|.|.||...: ||:||.|....|||||.|||.|..:.|||:|.: .|.
Zfish   168 IRSLVFYALRVWADPTLLEFHEVRGPEGADLQIDFLHGPHGDGYPFDGAGGSVGHAFFPSDPNRA 232

  Fly   227 GDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPD- 290
            |..|.||:|.|.|  ....:.||:...|.:|||||:|||.||:...:||.|:||     |.|.|
Zfish   233 GGVHLDAEEDWAF--RQPATEGTDLFTVLVHELGHALGLTHSSARRSVMRPYYQ-----GPLGDP 290

  Fly   291 -------DDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNN 348
                   .|...|..|||.:    |...|..|....|.|.:|
Zfish   291 LHFSLGYQDLQHITALYGQR----GNDIPTETPLPVTETQLR----------------------- 328

  Fly   349 DRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKI 413
                                                                       :|..::
Zfish   329 -----------------------------------------------------------HRHHRL 334

  Fly   414 EHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGARE 478
            .|
Zfish   335 TH--------------------------------------------------------------- 336

  Fly   479 PVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDS----CMTYYDAISIIRGELFIFRGPYLW 539
                               ::|..|.|       |||    |.|.:||::.||||:|.|:|..:|
Zfish   337 -------------------MYRHAHSH-------PDSSVDRCNTSFDAVAKIRGEIFFFKGQSMW 375

  Fly   540 RIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYE-NKQRQIVFFIGREYYVFNSVMLAPGFPKPL 603
            ||...||.:.....|:|.|||||.:|..:.||.| :....|:|..|.:.::|..:.|..|||:||
Zfish   376 RISRGGLVSVRVVPIQRLWSALPPSLPPLRAVLERHTDHAIIFISGSQVWLFKDLSLQDGFPQPL 440

  Fly   604 ASLGLPPTLTHIDASF-----------VWGHNNRTYMTSGTLYWR--IDDYTGQV--ELDYPRDM 653
                  |||...|..|           |||.............||  |:.....:  |.|:.|:
Zfish   441 ------PTLADSDGGFEGLRWDPTQGVVWGSIREEEQNEDNKVWRELIEGGVNGIIMENDHQRE- 498

  Fly   654 SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQ 718
               :..|:.         |.||.||...||:|............:|||..|:.|.:.::....:
Zfish   499 ---TNRGFK---------GSTYIFKGNSYWKFTHPGSAPVEGYPRLSASDWLDCPQDSSYSSAD- 550

  Fly   719 RWTASLVSE-GEETGRSGSRELRIN 742
               .||:|: |::......::..||
Zfish   551 ---ISLISQFGQQELHEQKKQTIIN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	69/172 (40%)
		ZnMc_MMP	143..301	CDD:239805	69/172 (40%)
		HX	513..707	CDD:238046	67/213 (31%)
mmp17b	NP_001352431.1	PG_binding_1	55..108	CDD:307564	16/52 (31%)
		ZnMc_MMP	145..308	CDD:239805	69/171 (40%)
		HX	350..540	CDD:238046	64/208 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920