DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp28

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_001337581.3	Gene:	mmp28 / 100005670	ZFINID:	ZDB-GENE-100226-1	Length:	501	Species:	Danio rerio

Alignment Length:	719	Identity:	177/719 - (24%)
Similarity:	274/719 - (38%)	Gaps:	233/719 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            ||.|..|:.|...:|.|.:|                       :|.|:.||.| |.||  .||.
Zfish     4 LLLLCVQTSCSSPISSPAQG-----------------------FLEQYGYLYK-DNET--YRTA- 41

  Fly    75 QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNL------YHEIGSNVR 133
            ::|.|||..|....:.|||.:|:||...:..|||||.|..|.|::. |.:      .|  |.::|
Zfish    42 EVKTAIREFQWLSWLPVTGHLDAATLEKMASPRCGVTDAGSIDAWQ-DRINGIFTGRH--GQHLR 103

  Fly   134 VRRFALQGPKWSRTDLTWSMVN--RSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQIL 196
            .:|:...|.||.:..|::.::|  ||: ..|:|...|..|..:|:|.|.|.|.|::...|||::.
Zfish   104 KKRYTQLGEKWQKKQLSYRILNWPRSL-STSQVHLAVSAAFQLWSNASGLQFLELHQGPADIRLA 167

  Fly   197 FARRAHGD--GYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHEL 259
            |....|.|  |..|||||..|||||:|..   |:||||..|.|...|..    |.|...|..||:
Zfish   168 FYDGEHNDGAGNAFDGPGGALAHAFFPFR---GEAHFDMSERWTLSGYK----GHNLFLVTAHEI 225

  Fly   260 GHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTM 324
            ||:|||.||.:..|:|.|:|:.......|..||...:|||||         ||       ...|:
Zfish   226 GHTLGLVHSPVRHALMSPYYKKISSNAVLSWDDITAVQQLYG---------KP-------PGDTV 274

  Fly   325 RAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEER 389
            :.::.||
Zfish   275 QQLVGRA---------------------------------------------------------- 281

  Fly   390 QRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQE 454
                 .||..:                 .|:.:..     |||
Zfish   282 -----LRWTMQ-----------------DWQISQD-----PRE---------------------- 297

  Fly   455 DRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTY 519
                                         ::.|                         |:.|..:
Zfish   298 -----------------------------SSLT-------------------------PNYCHGF 308

  Fly   520 YDAISI-IRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFI 583
            :|||:. ..|.:.:|:|...|.:....:.:  |..::..|..|  ::|...|.:....|::.||.
Zfish   309 FDAITTDENGAVLVFQGYRFWSVSNGSVSD--PCLLQTRWPQL--SVTIEAAAFNPLDRKLYFFK 369

  Fly   584 GREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELD 648
            ||..:.::...|.|||||..::||||   .|:|.:|.:....:..:..|:.|..::..:..:||.
Zfish   370 GRRMWRYSGSNLDPGFPKRSSALGLP---KHVDCAFFYQPLGQLVLFKGSRYLVLNPRSLSMELY 431

  Fly   649 YPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANE 713
            |||.:..|.||...::.|....||..||||...||..:..::::..|.....:.:|:.|.::.:.
Zfish   432 YPRPLRDWKGVPREVNGALTRPDGMLYFFKEQQYWRLDIGKLRITAAGRWADSLQWIGCQKTPSL 496

  Fly   714 VDDE 717
            :|:|
Zfish   497 LDNE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	64/161 (40%)
		ZnMc_MMP	143..301	CDD:239805	64/161 (40%)
		HX	513..707	CDD:238046	53/194 (27%)
mmp28	XP_001337581.3	PG_binding_1	21..70	CDD:279773	22/75 (29%)
		Peptidase_M10	113..267	CDD:278824	64/161 (40%)
		ZnMc_MMP	113..267	CDD:239805	64/161 (40%)
		HX	302..490	CDD:238046	53/194 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020