Protein Alignment Mmp2 and mmp21

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001304682.1
• Gene: mmp21 / 100003089
• ZFINID: ZDB-GENE-100226-2
• Length: 599
• Species: Danio rerio
• Alignment Length: 734
• Identity: 140/734 - (19%)
• Similarity: 227/734 - (30%)
• Gaps: 287/734 - (39%)

  Fly     5 YVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYL--------- 60
            :::.|.:.:.|:.:....       .||.......:|:.....|....:|.::.::
Zfish     9 FIIQTFIFITAEKIFHSR-------DHSDVLNNIHQAELITDTDTAQRFLSKYGFIKAAGSEESQ 66

  Fly    61 ---PKSDLE-------------TGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCG 109
               ...||:             :|:..::.|...|:|..|...::.|||..|.||...:.|||||
Zfish    67 LSESSGDLDFSLSLDLHEGGTTSGSSSSDLQFVSALRDFQRLSDLPVTGVFDDATKAAMNKPRCG 131

  Fly   110 VGD--------------RRSADSFSPDNLYHEIGSNVRVRRF---ALQGPK--------W----- 144
            |.|              |....:.:..:..||..:.||.:|.   .|:..|        |
Zfish   132 VMDDDQELKDVTGSNSTRNHIRTSTNTSHNHEHQAPVRKKRHLSALLKNTKLQKRDVSEWTGHMA 196

  Fly   145 -SRTDLTWSMVNRSMPDASKVER---MVQTALDVWANHSKLTF-REVYS--DQADIQILFARRAH 202
             |::.|.|.::.........::.   :.:.|..:|:..|.|.| .:::|  ...||::.|....|
Zfish   197 FSKSVLKWRLIGEGYSSQLSIQEQKYIFRLAFRMWSEISPLQFIEDLHSPLGNIDIRLGFGTGRH 261

  Fly   203 -GDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLA 266
             |...:|||.|:..|||::.     ||.|||.||.:..   .:...|.:.|.||:||:||.|||.
Zfish   262 LGCSQRFDGAGREFAHAWFL-----GDIHFDDDEHFTV---PNTGSGISLLKVAVHEIGHVLGLP 318

  Fly   267 HSAIPDAVMFPWYQNNEVAGNLPDD--------DRYGIQQLYGT-------------KEKTWGPY 310
            |...|.::|.|.|        ||.|        ||..||:|||.             ||:|  ||
Zfish   319 HIYRPGSIMQPSY--------LPQDAGFEIDWMDRKSIQRLYGVCMGRFSTVFDWIRKEQT--PY 373

  Fly   311 KPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEER 375
                     ....:|...|......||.:.|
Zfish   374 ---------GEVVVRFNTYFMRDGLYWLYEN---------------------------------- 395

  Fly   376 RHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRR 440
                                                                             
Zfish   396 ----------------------------------------------------------------- 395

  Fly   441 QEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHH 505
                                         |.||....:||.........|:......||..:
Zfish   396 -----------------------------RNNRTRYGDPVAVQVGWHGLPSGGVDAYVHVWN--- 428

  Fly   506 NKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLY--------NGYPTEIRRHWSALP 562
               ||.         ||:       :.|:|...||..:...:        ..||..|...:..:.
Zfish   429 ---RKT---------DAV-------YFFKGMQYWRYDSENDHVFSHAPDGRSYPRLISEDFPGVS 474

  Fly   563 ENLTKVDAVYENKQRQIVFFIGREYYVFNSVM--LAPGFPKPLASL------GLPPTLTHIDASF 619
            ..|.  .|.|:.:...|.||.|.:.:.|:..|  ||...|:.:..:      |..| :..:||::
Zfish   475 GPLD--TAYYDRRDAHIYFFKGSQVFRFDVRMRRLASSSPQEMTEVFPAIVSGDHP-VRSLDAAY 536

  Fly   620 VWGHNNRTYMTSGTLYWRI 638
            ....:|..::..|:|:||:
Zfish   537 FSYTHNTVFLLKGSLFWRV 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	54/186 (29%)
		ZnMc_MMP	143..301	CDD:239805	54/186 (29%)
		HX	513..707	CDD:238046	30/142 (21%)
mmp21	NP_001304682.1	PG_binding_1	<99..125	CDD:279773	9/25 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..170		4/28 (14%)
		Peptidase_M10	196..353	CDD:278824	52/172 (30%)
		ZnMc_MMP	197..353	CDD:239805	52/171 (30%)
		Hemopexin 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01011	356..415		15/197 (8%)
		HX	382..564	CDD:295316	44/327 (13%)
		Hemopexin 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01011	417..473		13/77 (17%)
		Hemopexin 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01011	474..522		12/49 (24%)
		Hemopexin 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01011	529..585		7/27 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.110