DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12926 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_610510.2	Gene:	CG12926 / 35996	FlyBaseID:	FBgn0033437	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	354	Identity:	77/354 - (21%)
Similarity:	134/354 - (37%)	Gaps:	94/354 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SLSPELAKKAHDELGEIPDRIDED-IE---------------TLRTWISKQPHLKARQDAQFLVA 59
            :|.|.|...:.|     .|::|.| ||               .||.|:.:....|..:| :.::.
Human   211 TLGPALEAVSMD-----GDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKD-EHILR 269

  Fly    60 FLRGCKYSLEKTKLKLDNFYAMRGAVPELYKNRIVGEKQLSILDTGCLLRLPQP----------- 113
            |||...:.|:|.:              |:.:..:...||..:   ..||:..||
Human   270 FLRAHDFHLDKAR--------------EMLRQSLSWRKQHQV---DLLLQTWQPPALLEEFYAGG 317

  Fly   114 ---LQADGPRIHISRYGQYDSK--------KYSIAEVVQVNTMLGEIQIREDDNAM-----ISGF 162
               ...||..::|.|.||.|:|        :..:..|:.||.   |.|.|.:.:..     ||.:
Human   318 WHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNE---EGQKRCEGSTRQLGRPISSW 379

  Fly   163 VEIIDMKGVGAGHLFQFDA-VLVKKLAVLGDKAYPYRPKGFHFVNAPSSAEKFMSIAKSLMSEKI 226
            ..::|::|:...||::... .|::.:.|:.|. ||........|.||.......::....::|..
Human   380 TCLLDLEGLNMRHLWRPGVKALLRMIEVVEDN-YPETLGRLLIVRAPRVFPVLWTLISPFINENT 443

  Fly   227 RKRFHIHSKLD-----SLYKYVPKECLPAEYGGSNGTIQDVVSTWRTKLLAYKPFFEEEASYGTN 286
            |::|.|:|..:     .|..|:.:|.:|...||     :.|.:.....|:....:..||....|:
Human   444 RRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGG-----ESVCNVPEGGLVPKSLYMTEEEQEHTD 503

  Fly   287 E-----------KLRRGQP--VSAESLFG 302
            :           .:.||.|  |:.|.|.|
Human   504 QLWQWSETYHSASVLRGAPHEVAVEILEG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12926	NP_610510.2	CRAL_TRIO_N	32..77	CDD:215024	14/60 (23%)
CG12926	NP_610510.2	SEC14	117..254	CDD:238099	37/155 (24%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		1/2 (50%)
		CRAL_TRIO_N	243..288	CDD:215024	11/59 (19%)
		SEC14	306..479	CDD:214706	40/181 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810