DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12926 and TTPAL

DIOPT Version :9

Sequence 1:	NP_610510.2	Gene:	CG12926 / 35996	FlyBaseID:	FBgn0033437	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_001034288.1	Gene:	TTPAL / 79183	HGNCID:	16114	Length:	342	Species:	Homo sapiens

Alignment Length:	297	Identity:	89/297 - (29%)
Similarity:	143/297 - (48%)	Gaps:	22/297 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SLSPELAKKAHDELGEIPDRIDEDIETLRTWISKQ-PHLKARQDAQFLVAFLRGCKYSLEKTKLK 74
            ||:.:|..||.:||.|.|:....|::.||..:.|: |:|....|..||:.|||..|:..::....
Human    34 SLTEDLVTKAREELQEKPEWRLRDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQL 98

  Fly    75 LDNFYAMRGAVPELYKNRIVGEKQLSILDTGCLLRLPQPLQADGPRIHI--SRYGQYDSKKYSIA 137
            |.|:::.|.:.||:: |.:.......:|.:|.|..||   ..|....|:  .|..::....|.|.
Human    99 LVNYHSCRRSWPEVF-NNLKPSALKDVLASGFLTVLP---HTDPRGCHVVCIRPDRWIPSNYPIT 159

  Fly   138 EVVQVNTMLGEIQIREDDNAMISGFVEIIDMKGVGAGHLFQFDAVLVKKLAVLGDKAYPYRPKGF 202
            |.::...:..| ::.:.:...::|.|.:.|.|||.......|...:.||:..:....:|.|.|..
Human   160 ENIRAIYLTLE-KLIQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAV 223

  Fly   203 HFVNAPSSAEKFMSIAKSLMSEKIRKRFHIH-SKLDSLYKYVPKECLPAEYGGSNGTIQDVVSTW 266
            |.||.|...:...:|.|..:.|||..||.:| |.|:||:..:|:..||.||||:.|.:.  .:||
Human   224 HVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGTAGELD--TATW 286

  Fly   267 RTKLLAYKPFFEEEASYGTNEKLRRGQPVSA-ESLFG 302
            ...|||.:..|.:|..          |||.| :|:.|
Human   287 NAVLLASEDDFVKEFC----------QPVPACDSILG 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12926	NP_610510.2	CRAL_TRIO_N	32..77	CDD:215024	14/45 (31%)
CG12926	NP_610510.2	SEC14	117..254	CDD:238099	40/139 (29%)
TTPAL	NP_001034288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		CRAL_TRIO_N	56..102	CDD:215024	14/45 (31%)
		SEC14	121..277	CDD:238099	46/159 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1031056at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920