DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12926 and Ttpa

DIOPT Version :9

Sequence 1:	NP_610510.2	Gene:	CG12926 / 35996	FlyBaseID:	FBgn0033437	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_037180.1	Gene:	Ttpa / 25571	RGDID:	3915	Length:	278	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	71/260 - (27%)
Similarity:	122/260 - (46%)	Gaps:	38/260 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ELAKKAHDELGEIPDRIDEDIETLRTWISKQPHLKARQDAQFLVAFLRGCKYSLEKTKLKLDNFY 79
            ||.::|.:|  .:|:             :.||...|     ||:.|||...:.|:.....:.|:|
  Rat    30 ELRRRAQEE--GVPE-------------TPQPLTDA-----FLLRFLRARDFDLDLAWRLMKNYY 74

  Fly    80 AMRGAVPE----LYKNRIVGEKQLSILDTGC--LLRLPQPLQADGPRIHISRYGQYDSKKYSIAE 138
            ..|...||    |:...|:|     :|..|.  :||...|   .|.|:.|.|...:|.|.::..:
  Rat    75 KWRAECPELSADLHPRSILG-----LLKAGYHGVLRSRDP---TGSRVLIYRISYWDPKVFTAYD 131

  Fly   139 VVQVNTMLGEIQIREDDNAMISGFVEIIDMKGVGAGHLFQFDAVLVKKLAVLGDKAYPYRPKGFH 203
            |.:|:.:..|:.::|.:... :|...|.|::|....|.||....:.||:|.:...::|.:.:|.|
  Rat   132 VFRVSLITSELIVQEVETQR-NGVKAIFDLEGWQISHAFQITPSVAKKIAAVVTDSFPLKVRGIH 195

  Fly   204 FVNAPSSAEKFMSIAKSLMSEKIRKRFHIHSK--LDSLYKYVPKECLPAEYGGSNGTIQDVVSTW 266
            .:|.|.......|:.|..::|||:.|.|:|..  ..||.::.| :.||.||||:..:::|:...|
  Rat   196 LINEPVIFHAVFSMIKPFLTEKIKGRIHLHGNNYKSSLLQHFP-DILPLEYGGNESSMEDICQEW 259

Fly 267 266
Rat 260 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12926	NP_610510.2	CRAL_TRIO_N	32..77	CDD:215024	9/44 (20%)
CG12926	NP_610510.2	SEC14	117..254	CDD:238099	40/138 (29%)
Ttpa	NP_037180.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		CRAL_TRIO_N	25..73	CDD:215024	14/62 (23%)
		CRAL_TRIO	99..248	CDD:395525	45/153 (29%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920