DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12926 and CLVS1

DIOPT Version :9

Sequence 1:	NP_610510.2	Gene:	CG12926 / 35996	FlyBaseID:	FBgn0033437	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	302	Identity:	81/302 - (26%)
Similarity:	129/302 - (42%)	Gaps:	63/302 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSPELAKKAHDELGEIPDRIDEDIETLRTWISKQPHLK-ARQDAQFLVAFLRGCKYSLEKTKLKL 75
            ||||..:||..||.|.||.:.:||:.:|..|..:|.:. .|.|..|::.|||..|:........|
Human    30 LSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLL 94

  Fly    76 DNFYAMRGAVPELYKNRIVGEKQLSILDTGCLLRLPQPLQADGPRI-------------HISRYG 127
            ..::..|....:::||                      .:||.|.|             :...||
Human    95 AQYFQYRQLNLDMFKN----------------------FKADDPGIKRALIDGFPGVLENRDHYG 137

  Fly   128 Q---------YDSKKYSIAEVVQVNTMLGEIQIREDDNAMISGFVEIIDMKGVGAGHLFQFDAV- 182
            :         :|..:.|..::::...:..|:.| ||....|:||:.|||...      |.|...
Human   138 RKILLLFAANWDQSRNSFTDILRAILLSLEVLI-EDPELQINGFILIIDWSN------FSFKQAS 195

  Fly   183 ----LVKKLAVLG-DKAYPYRPKGFHFVNAPSSAEKFMSIAKSLMSEKIRKRFHIH-SKLDSLYK 241
                .:.|||:.| ..::|.|..|.||||.|.......::.|..:.:|.|||..:| :.|:||::
Human   196 KLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQ 260

  Fly   242 YVPKECLPAEYGGSNGTIQDVVSTWRTKLLAYKPFFEEEASY 283
            .:..|.||:|:||:.....  :.||...||.  |.:.:|..|
Human   261 LIHPEFLPSEFGGTLPPYD--MGTWARTLLG--PDYSDENDY 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12926	NP_610510.2	CRAL_TRIO_N	32..77	CDD:215024	13/45 (29%)
CG12926	NP_610510.2	SEC14	117..254	CDD:238099	44/165 (27%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	13/45 (29%)
		CRAL_TRIO	125..274	CDD:306996	42/155 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750