Protein Alignment GstT1 and CLIC2

DIOPT Version :10

• Sequence 1: NP_610509.2
• Gene: GstT1 / 35995
• FlyBaseID: FBgn0050000
• Length: 228
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 42/204 - (20%)
• Similarity: 75/204 - (36%)
• Gaps: 67/204 - (32%)

  Fly    19 LWI-AMKLGKTPFEDCPVALRKQEQLTDEYRSINRFQKVPAIVDGKFQLGESVSIVRYLADKGVF 82
            ||: .:|...|..:    ..||.|:|.|.....|     |..:                    |:
Human    40 LWLKGVKFNVTTVD----MTRKPEELKDLAPGTN-----PPFL--------------------VY 75

  Fly    83 SEQLYPKTLEERARVDEFLE-------WQHFNVR------LVCSLFFRQVWLLPAKGLAPAPKPE 134
            :::|  ||  :..:::||||       :.|.:.:      :.|:||.:  :....|.........
Human    76 NKEL--KT--DFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAK--FSAYIKNTQKEANKN 134

  Fly   135 SVKKLIKDVES-----NLGLLERLWLEKD-----------FLVGDKLTVADIFGSSEINQMKLCQ 183
            ..|.|:|:.:.     |..||:.  ::.|           ||.||:||:||.....::|.:|:..
Human   135 FEKSLLKEFKRLDDYLNTPLLDE--IDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAA 197

  Fly   184 YNVNEKQFP 192
            ....:...|
Human   198 KKYRDFDIP 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstT1	NP_610509.2	GST_N_Theta	5..80	CDD:239348	11/61 (18%)
		GST_C_Theta	93..218	CDD:198292	27/129 (21%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		19/88 (22%)
		N-terminal	1..94		19/86 (22%)
		O-ClC	12..245	CDD:129941	42/204 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		1/10 (10%)
		C-terminal	107..247		22/104 (21%)
		Foot loop	151..171		4/21 (19%)