Protein Alignment Urod and HEM12

DIOPT Version :10

• Sequence 1: NP_610501.1
• Gene: Urod / 35986
• FlyBaseID: FBgn0033428
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_010332.3
• Gene: HEM12 / 851617
• SGDID: S000002454
• Length: 362
• Species: Saccharomyces cerevisiae
• Alignment Length: 355
• Identity: 170/355 - (47%)
• Similarity: 227/355 - (63%)
• Gaps: 7/355 - (1%)

  Fly     7 FPVLKNDNLLRAARGEVVDRVPVWVMRQAGRYLPEFQELRKHHDFFTVCRTPELACEVTMQPLRR 71
            ||..|||.:||||:||.|:|.|.|:||||||||||:.|::.:.|||..||..|:|.|:|:||:||
Yeast     4 FPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLPEYHEVKNNRDFFQTCRDAEIASEITIQPVRR 68

  Fly    72 FD--LDASIIFSDILVIPQALGLTVEMHAGVGPVLPQPIVVPEDLKRLT--PDGALSRLSYVGDA 132
            :.  :||:||||||||||||:|:.|||..|.||..|:|:..||||:.:.  ....|..|.:...|
Yeast    69 YRGLIDAAIIFSDILVIPQAMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDVLKELDWAFKA 133

  Fly   133 ITMMRHKLEGRVPLIGFTGAPWTLMGYMIEGGGSKTMSKAKAWLNEHPEDSKLFLNLLTDAIVDY 197
            |||.|.||:|.|||.||.|.|||||.||.|||||:....||.|:|.:||.|...|..:||..|::
Yeast   134 ITMTRIKLDGEVPLFGFCGGPWTLMVYMTEGGGSRLFRFAKQWINMYPELSHKLLQKITDVAVEF 198

  Fly   198 LEMQVKAGAQMLQVFESSAEHLSKEQFLQWCVPYLKRIRDELVDRLTKKAI-PVVPMTLFAKGAG 261
            |..||.||||:||||||....||...|.::.:|||::|.:.:..||.:..| ..:||.:||||:.
Yeast   199 LSQQVVAGAQILQVFESWGGELSSVDFDEFSLPYLRQIAERVPKRLQELGIMEQIPMIVFAKGSW 263

  Fly   262 HSLKEQSELGYDVIGLDWTVDPLEARNLVGPNITLQGNLDPQDMYRDPDELRNLTTEMVHKF--G 324
            ::|.:....|:||:.|||:.||.||..:....:||||||||..||...:.:.....:|:..|  |
Yeast   264 YALDKLCCSGFDVVSLDWSWDPREAVKINKNRVTLQGNLDPGVMYGSKEVITKKVKQMIEAFGGG 328

  Fly   325 KSRYIANLGHGITPQTPITSMEVLVEAVHK 354
            |||||.|.|||..|......::..:|..|:
Yeast   329 KSRYIVNFGHGTHPFMDPDVIKFFLEECHR 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Urod	NP_610501.1	hemE	14..354	CDD:273640	164/346 (47%)
HEM12	NP_010332.3	URO-D	13..358	CDD:238368	164/344 (48%)