DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and smyd4

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_012812690.1	Gene:	smyd4 / 779741	XenbaseID:	XB-GENE-945037	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	181/770 - (23%)
Similarity:	292/770 - (37%)	Gaps:	164/770 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERLARTFSQQNELI--TLNENYKDEFETFKSLASMPADILQIFQKLALDLLQDLEQPVDRKGC- 62
            ||...:.:..|.:.|  .|..:.|::|.:.       ||:.:|||.....|.||.||.::|..|
Frog    39 MEHPVQEWQDQAQSIWAHLTSSEKEKFSSI-------ADLDEIFQACLSHLQQDEEQLIERLCCN 96

  Fly    63 --AERSKN----LREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIAL 121
              ..:..|    .:||||..|.|....:       |..|||:|:..|::..|.|::.||||..||
Frog    97 VTVAKDPNAVQFFKEEGNKRFAEKQYAT-------AAGLYSKAISHAKSGSEALAVCFANRSAAL 154

  Fly   122 QEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQ 186
            ...|.|....:|..:|.:.|||||||:|::.|:|.|..:|:|.:|.:..|:.:..::.|:..:..
Frog   155 FYLGQYSVCLEDIQHAQDHGYPERLRNKILQRKAECFQRLRKPSSCDPKLECVETVKPKKEPQTS 219

  Fly   187 LEDLKQKLELLKNQPREQETQGKVVDKSLGEILTDPGPRGRYMVAKEAISKGNVIFSER--ASCF 249
            .|.||:.  .|...|.       :.:.|....|.....:||:::|.:.|.:|.|:..|.  ||..
Frog   220 TERLKEM--ALDRNPH-------ITNASCALHLNFDTRKGRHLLASQNIEQGEVLIWEEAFASVI 275

  Fly   250 VPLEQLL---------------ICQQCAATLMSAPIPCPNCHQRVVYCSRKCRE-AHSAIHKFEC 298
            :|..:..               .|..|...:: |.:||..| ....|||::|.: |..:.|..||
Frog   276 IPERKQWRKEIKWDTRITACDHYCHYCLNRVI-ASLPCQYC-SFARYCSQECMDKAWRSYHYIEC 338

  Fly   299 AAYRKDILRLLGI-SHLALR-LLLTYIPYIRPHLQEMTSAK-------------------GMWEE 342
            :  ..|:|..||: .|.||| :|:.........|::..||.                   ..::.
Frog   339 S--MGDLLLALGMFCHTALRAVLVAGCRLFSQSLEQTGSADATDKTKVCNSKNTYHEKYCSSYQS 401

  Fly   343 IMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPAS 407
            ::||....|......::|..|...:.          |..||..:.:..:...:...........:
Frog   402 VVNLLPHTENHPAERKFLCGLTAAAL----------YKKLCLIMAKDLVSSTSQTEKSLTKESGT 456

  Fly   408 IEDWQLI---ISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLS 469
            ||||..:   :...:||...||..|.....||                  |:........|...:
Frog   457 IEDWSSVRQFLGPTVLRHMLQLYCNAQAVTAL------------------QENEDESSLSLVKSN 503

  Fly   470 HSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCY-----TMDYRNSLK 529
            .|..:.....|.|||.||:|:|:....|.|..|...|.:.|...||:.:||     .||.
Frog   504 KSIRLATAVFPVLSLLNHSCDPNTTVSFTGRFVTVRANRPIRRDEEVTHCYGPHKLRMDV----- 563

  Fly   530 LQRSHPLKAIYKFECTCAKCTRTDPDQNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNA 594
            .:|...||..|.|.|.|..||.   :......|.:.|  |.|:.:.                 ..
Frog   564 AERQQLLKDQYFFVCQCKACTE---ELKGKKTHGFFC--PLCKAQL-----------------EG 606

  Fly   595 EKPITCT------VCHELQHFAWYNEFLG---------LIGSSADSSKRQALFKAFDDLDKWLVD 644
            |:.:.||      ...:.|..:..|: ||         |..:..|::| ..|.....:.:.:|..
Frog   607 EEALYCTGARCTYTASQTQLTSRLNQ-LGNHIQIAKVQLQDNKTDNAK-MTLMSCLSEAECFLSQ 669

  Fly   645 HHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARIIRKQLEGIAAQCGDNSTE 699
            .|.|...:.:.|..|   |...|      .::..|..:||.:..:....|.:|.|
Frog   670 DHLLLGEIMDHLAQA---EASDG------NWKAAAGHLRKSISIVKVHYGSSSME 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	12/40 (30%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	22/83 (27%)
smyd4	XP_012812690.1	TPR repeat	106..134	CDD:276809	11/34 (32%)
		TPR_11	107..170	CDD:290150	23/69 (33%)
		TPR repeat	143..173	CDD:276809	11/29 (38%)
		zf-MYND	299..338	CDD:280009	12/40 (30%)
		SET	<509..555	CDD:279228	16/45 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050