DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and smyd4

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001070062.1	Gene:	smyd4 / 767654	ZFINID:	ZDB-GENE-060929-248	Length:	753	Species:	Danio rerio

Alignment Length:	848	Identity:	192/848 - (22%)
Similarity:	305/848 - (35%)	Gaps:	266/848 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DEFETFKSLASMPADI---LQIFQKLALDLLQDLEQPVDRKGCAERSKNLREEGNLMFKESASGS 84
            :|.|.|..|..:.|..   |.:.....|::|..:.:....|...|.:...|::|||.||
Zfish    22 EETERFSLLTDIDAIFNYGLSLICPEDLNILSRISEKFSVKKSPETASEFRQQGNLSFK------ 80

  Fly    85 SKD---SVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERL 146
            .||   :||.    ||:.|..|:...:||||.:|||..||...|.|:...:|...:||.|||..|
Zfish    81 VKDYPAAVLH----YSKGVCHADKNTDELSLCYANRSAALFYQGLYQACLEDIRRSLEAGYPSHL 141

  Fly   147 RHKVIMRQAFCAWKLKKIASLE-EHLDYLGQLQLKESFEQQLEDLKQKLELLKNQPREQETQGKV 210
            :.|:..||..|..:|:|..... .|.|:            ||...             |:|....
Zfish   142 QDKLQTRQTACQNQLRKAEKPNIPHTDH------------QLSPC-------------QKTVNST 181

  Fly   211 VDKSLGEILTDPGPRGRYMVAKEAISKGNVIFSERASCFVPLEQLLI-----------------C 258
            ...|.|..:.....:||:|:..|....|.|:..:.|.|.|.:...:.                 |
Zfish   182 GHLSDGVSVYFSSDKGRHMLVMENKPAGEVVLEDEAYCSVLIPANIFNTGTNKAVETFGTEDRHC 246

  Fly   259 QQCAATLMSAPIPCPNC-HQRVVYCSRKC-REAHSAIHKFECAAYRKDILRLLGISHLALRLLLT 321
            ..|.:..:|. :|||.| :.|  ||...| ::|....|::||.. ..|:|.:..:.|||||::|
Zfish   247 HHCLSQSLSF-VPCPKCSYAR--YCGESCQKDAWDQWHQWECPV-GADLLAIGVLGHLALRVVL- 306

  Fly   322 YIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANL 386
                          ..|..|..|.:       :|..:::.:.:..|.:..::..:      |...
Zfish   307 --------------KAGQTEVQMGI-------KNTKDHVTTYKNDSPVQLSLGGD------CGKS 344

  Fly   387 LQLYLKEHTD-----FYDQFHSL--------PASIEDWQLIISALILRFAGQLLANGHVGDALLG 438
            |     :|||     .|...:||        |||    :.:::..:....|:|..
Zfish   345 L-----DHTDCFHGSSYMGIYSLLPHVAQHSPAS----RFLMAITMAVIYGKLQG---------- 390

  Fly   439 VGMEPKEFVMLQPE----LWQKP---------RHLKRGQLHNLSHSDPITAINL----------- 479
             |..|.:::..:.|    .||..         ||:.  ||.  .::..|||:.:
Zfish   391 -GPPPNKWMSFKDEGVKASWQPEMSMLGATALRHMM--QLR--CNAQAITAVRVKEESGMAVQSS 450

  Fly   480 ----------PYLSLCNHACEPSIRTKFD-----------GCS---------------VVNYAAK 508
                      |.|||.||:|.|:....|.           |||               |...|:|
Zfish   451 SEIRIATAIFPVLSLLNHSCSPNTSISFTTGFQPDPHNQLGCSEGHFDHPKGSRSGVTVTVRASK 515

  Fly   509 DILEGEEIFNCYTMDYRNSLKL-QRSHPLKAIYKFECTCAKCTRTDPDQNYLSFHRYRCEKPNCR 572
            |:..|:||.:||. .:|:.::: :|...|...|.|:|.|..|.| |..:.          .||.:
Zfish   516 DLTAGQEILHCYG-PHRSRMEVKERQRLLLEQYFFQCVCQACQR-DLSEG----------SPNAK 568

  Fly   573 QEFLPDAKVQQNNLRWWLRCNAEKPI-------TCT------------VCHELQHF-AWYNEFLG 617
            :...|..|.        ::|.  ||:       ||:            |.:.||.| ...:|.:.
Zfish   569 EHTAPGMKC--------VKCG--KPLQSHTDGYTCSWSSCGHQISSADVQNRLQGFQLLLDEAVH 623

  Fly   618 LIGSSADSSKRQALFKAFDDLDKWLVDHHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARII 682
            |:.....:.....|..||...:..|.:.|..:..:|:.|  |..|...|..||       .|..:
Zfish   624 LMEQDRLNEALHILQSAFSQANSILTETHPFQGELADAL--ARLYASTGEWSL-------AASHL 679

  Fly   683 RKQLEGIAAQCGDNSTE-----------------------YIARMTYLWDIIAQKKCRTDRKELL 724
            ::.|..|.||.|::|.|                       .|.|...|..:....:|. :.:||.
Zfish   680 KRSLVAIQAQFGEDSIELGRQLFKLAQLHFNGRDGVASLSVIPRARRLLSLHCSPRCE-ELQELS 743

  Fly   725 EMK 727
            ||:
Zfish   744 EME 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	13/41 (32%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	31/138 (22%)
smyd4	NP_001070062.1	TPR_11	68..134	CDD:290150	26/75 (35%)
		TPR repeat	68..96	CDD:276809	12/37 (32%)
		TPR repeat	101..134	CDD:276809	12/32 (38%)
		zf-MYND	246..285	CDD:280009	13/41 (32%)
		SET	<456..532	CDD:214614	21/76 (28%)
		T6SS_VasJ	<603..679	CDD:299836	19/84 (23%)
		TPR_12	615..683	CDD:290160	15/76 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582735
Domainoid	1	1.000	65	1.000	Domainoid score	I10044
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107370
Panther	1	1.100	-	-	LDO	PTHR46165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.780