DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and SmydA-5

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	102/529 - (19%)
Similarity:	156/529 - (29%)	Gaps:	221/529 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 GRYMVAKEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPCPNC--------HQ----R 278
            |||:...:.|:.|.::|.|......|...|....:.|:.     :||..|        ||    |
  Fly    55 GRYLKVTQNIAAGQIVFIEEPLVVGPKWYLSDADKEASN-----VPCVGCYTPCRLGKHQCRRCR 114

  Fly   279 VVYCSRKCREAHSAIHKFECAAY--------RKDILRL----LGISHLALRLLLTYIPYIRPHLQ 331
            ...||..|:  |.::   ||:..        |.|...|    .|.:.|.|:.||         ||
  Fly   115 WPVCSAGCK--HESM---ECSVLSLGSGSPTRADARSLNDYFRGDALLVLKCLL---------LQ 165

  Fly   332 EMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTD 396
            ..:..|  |..::.:....||                                       ::.||
  Fly   166 RQSPTK--WSALLEMQSHEEE---------------------------------------RKGTD 189

  Fly   397 FYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLK 461
            .|:         |..:.:::.|..||..:|...            .|.......||:
  Fly   190 LYE---------EAEKRVVTYLQKRFLCRLKQT------------NPNLLTDCGPEM-------- 225

  Fly   462 RGQLHNLSH--SDPITAINLP--------YLSLC--NHACEPSIRTKFDGCS--VVNYAAKDILE 512
               ||.|..  ......|.||        :...|  .|||:|:...:||..:  |...|..|:.:
  Fly   226 ---LHRLCGIIETNFMVIELPSGVELSGLFRQACMMEHACQPNCDFQFDNKTQQVAVRAGCDLRK 287

  Fly   513 GEEIFNCYTMDYRNSL--KLQRSHPLKAIYKFECTCAKCTRTDPDQ--NYLSFHRYRCEKPNCRQ 573
            |:.:    .:.|.|.|  ...|.|.|:....|.|.|::|  .||.:  .|:|.
  Fly   288 GDHL----RITYTNILWGTQLRQHHLRLTKHFSCRCSRC--LDPTEYGTYISA------------ 334

  Fly   574 EFLPDAKVQQNNLRWWLRCNAEKPITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDDL 638
                            |.|..:...||...|                            ...|.|
  Fly   335 ----------------LTCLGDVNQTCGGTH----------------------------LPVDPL 355

  Fly   639 D---KWLVDHHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARIIRKQLEGIAAQC-GDNSTE 699
            |   :|..|              .|...:||.      ...:|...:.:|:||:.|.| ..|..|
  Fly   356 DENTQWKCD--------------TCPMIVDGA------YVAELQSHMTEQVEGLLAGCPSANQVE 400

  Fly   700 -YIARMTYL 707
             .:||:|::
  Fly   401 LLLARLTHM 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	11/51 (22%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	20/92 (22%)
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830