DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP011233

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_564259.2	Gene:	AgaP_AGAP011233 / 3291278	VectorBaseID:	AGAP011233	Length:	393	Species:	Anopheles gambiae

Alignment Length:	407	Identity:	84/407 - (20%)
Similarity:	151/407 - (37%)	Gaps:	103/407 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EQPVDRKGCAERSKNLREEGNL---------MFKESASGSS-----KDSVLKACRLYSEAVFEAE 104
            |:.||:.....||..:|::.||         .....|.|::     ..:.::|.:.::.::...|
Mosquito    49 ERFVDQIIILVRSGGIRDQLNLAPDVKGHVAALAYRAQGTALYHPRVCNYIEALKYFNASIAHTE 113

  Fly   105 -NAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLE 168
             |:|:. .:|:|||.|...|...|.:...:...|....||.|...|:..|:|.....|:::.::.
Mosquito   114 LNSVDR-GIAYANRSIVCMELHQYEDCVANVRLARASNYPVRFLPKLAAREARAQHALQRVRTIN 177

  Fly   169 EHLDYLGQLQLKESFEQQLEDLKQKLELLKNQPREQETQGKVVDKSLGEILTDPGPRGRYMVAKE 233
            ......|....:.:::||          .|.||        .......|:.|..||....:..
Mosquito   178 ARKQKNGHRSAERNWQQQ----------EKKQP--------TAANGAEELSTKLGPHLHGLAV-- 222

  Fly   234 AISKGNVIFSERASCFVPLEQLLI-CQQCAATLMSAPIPCPNCHQRVVYCSRKC-REAHSAIHKF 296
                            |..|||.. |..|.:..:...|||..| ...::||..| .||:...|::
Mosquito   223 ----------------VEYEQLYARCNYCHSRRLFTFIPCEGC-TVAMFCSVACLTEAYRKYHRY 270

  Fly   297 ECAAYRKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLR 361
            ||...| |:.::.|                   .:.:|:.:.:..|:.:....|    ::.|||.
Mosquito   271 ECGLVR-DLWKIGG-------------------AEAVTAFRRVAAELASFPDVP----SSVEYLE 311

  Fly   362 SL-------RMVSQLDQAIDEE-----LNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQL- 413
            ..       .:...|:.|..:|     |:|.|...:::...:.|.|..  :|    ..|||.::
Mosquito   312 LFVAMKGYCAVADGLEGATVQENDHRQLSYRIFLTDIIHQLMVERTVL--RF----CCIEDPRIS 370

  Fly   414 -IISALILRF----AGQ 425
             ::..|||.:    |||
Mosquito   371 RLLFELILYYLTSCAGQ 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	12/40 (30%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614
AgaP_AGAP011233	XP_564259.2	TPR_11	80..148	CDD:290150	14/68 (21%)
AgaP_AGAP011233	XP_564259.2	zf-MYND	232..272	CDD:280009	12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820