DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP011234

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_564258.1	Gene:	AgaP_AGAP011234 / 3291277	VectorBaseID:	AGAP011234	Length:	646	Species:	Anopheles gambiae

Alignment Length:	577	Identity:	131/577 - (22%)
Similarity:	222/577 - (38%)	Gaps:	143/577 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QIFQKLALDLLQD-LEQPVDRKGCAERSKNL--REEGNLMFKESASGSSKDSVLKACRLYSEAVF 101
            :|...|...||:: |....|.|   :.:|.|  |..||.:|....   .||  |:|.:.|:|::.
Mosquito    46 EIEDYLRTSLLRERLHLQPDTK---DNAKALAARNRGNELFVPKL---GKD--LEALQHYNESIA 102

  Fly   102 EAENAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIAS 166
            .:|...|..:||:.:|.:...::..::|..::...|....||.||..::..|:.:.    ||..:
Mosquito   103 YSEPGSEARALAYGDRSVVCLKFNLFKECLENIRLARASNYPARLADQLSEREQYA----KKCLN 163

  Fly   167 LEEHL----------DY----LGQLQLKESFE--QQLEDLKQKLELLKNQPREQETQGKVVDKSL 215
            |...:          .|    .|:..|:.|:|  :.:..|.:.:||      .|:::
Mosquito   164 LLPPIFPDPARRTPGKYRPRGTGRPALQLSYEAHRNIPHLVKCVEL------RQDSE-------- 214

  Fly   216 GEILTDPGPRGRYMVAKEAISKGNVIFSER--ASCFVPLEQLLICQQCAATLMSAPIPCPNCHQR 278
                     .||::|..:.:..|:|:..|:  ||.....:|...|..|........|||..| ..
Mosquito   215 ---------FGRHLVTTQHLKAGDVLMIEKPYASLLCERDQYKRCAFCHNEDTFTLIPCEGC-TV 269

  Fly   279 VVYCSRKCRE-AHSAIHKFECAAYRKDILRLLGI---SHLALRLLLTYIPYIRPHLQEMTSAKGM 339
            .:|||.:||: ||...|::|||..| |..|.:|.   ..|.||.:.|       .......:.|.
Mosquito   270 AMYCSEECRDKAHKQYHRYECAVLR-DCWRSVGFPVEMLLGLRTVAT-------AFASFDQSLGQ 326

  Fly   340 WEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEEL--NYHILCAN----------------- 385
            |  |..:....|...||        .....::|.|.::  ..|:|..|
Mosquito   327 W--IYRMETLDETKVNA--------FTVDWNKATDRDIYDTVHVLATNQNRRDHKQLASLIFFAY 381

  Fly   386 LLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQ 450
            ::|..|.:.|:......|.|:.    :.::..|:||.....|.|.:        .:...|.|.|:
Mosquito   382 IVQGLLLDRTELRPLCWSCPSR----RKLLFELLLRHTQTALTNKN--------DVYHMERVKLE 434

  Fly   451 PELWQKPRHLK-----------------RGQLHNLSHSDPITAINL-PYLSLCNHACEPSIRT-- 495
            .:      |::                 |....|:.|.:...||.: |..|:.||:|.|::..
Mosquito   435 DD------HVEDDESEEDSSVDNNNSDDRKSPRNVHHEERTHAIAIYPLFSMVNHSCIPNVAPIH 493

  Fly   496 KFDGCSVVNYAAKDILEGEEIFNC---YTMDYRNSLKLQRSHPLKAIYKFECTCAKC 549
            ..|| .:...|.:.|..||:::|.   .|.|..:|   .|.|.|:..:.|:|.||.|
Mosquito   494 LLDG-RLAMVATRPIAAGEQLYNINGFSTFDPDDS---ARRHALQLSHFFKCRCASC 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	14/40 (35%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	23/101 (23%)
AgaP_AGAP011234	XP_564258.1	TPR_11	71..140	CDD:290150	19/73 (26%)
		zf-MYND	250..290	CDD:280009	14/40 (35%)
		SET	<479..515	CDD:279228	11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820