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Protein Alignment Smyd4-1 and Smyd4

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001096081.1	Gene:	Smyd4 / 319822	MGIID:	2442796	Length:	799	Species:	Mus musculus

Alignment Length:	872	Identity:	194/872 - (22%)
Similarity:	310/872 - (35%)	Gaps:	263/872 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DEFETF--KSLASMPADILQIFQKLALDLLQD-------LEQPVDRKGCAERSKN---------- 68
            ||::::  |..||:|..:.....  ..:.|.|       |.||.|.....|.|.:
Mouse     6 DEWKSYLLKKWASLPKSVQDTIS--TAETLSDIFLPSSSLLQPEDEMFLKELSSSYSVEKDNDAP 68

  Fly    69 --LREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAY 131
              .|||||..|:|.       ....|..|||:.|..:....|::||.:|||..||...|.|....
Mouse    69 LFYREEGNRKFQEK-------EYTDAAVLYSKGVSHSRPNTEDISLCYANRSAALFHLGQYEACL 126

  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQL-----EDLK 191
            .|...|...||||||:.|:::|:..|   |..:..|:|....:..|:...:.:..|     :.|:
Mouse   127 KDIVEAGMHGYPERLQPKMMVRKTEC---LVNLGRLQEARQTISDLESSLTAKPTLVLSSYQILQ 188

  Fly   192 QKLELLKNQPREQETQGKVV---------DKSLGE-------------ILTDPGPRGRYMVAKEA 234
            :.::.||.:.:|:||..:.:         |.:|||             :.|.| .:||::||.:.
Mouse   189 RNVQHLKIKIQEKETLPEPIPAALTNAFEDIALGEENTQISGASLSVSLCTHP-LKGRHLVATKD 252

  Fly   235 ISKGNVIFSERA--SCFVPLEQL------------------LICQQCAATLMSAPIPCPNCHQRV 279
            |..|.::..|.|  |..:|.|..                  |.|.:|....: |.:||.:| ...
Mouse   253 ILPGELLVKEDAFVSVLIPGEMPRPHHCLENKWDTRVTSGDLYCHRCLKHTL-ATVPCGSC-SYA 315

  Fly   280 VYCSRKC-REAHSAIHKFECAAYRKDILRLLGI-SHLALRLLLTYIPYIRPHLQEMTSAKGMWEE 342
            .|||::| ::|....|..||:.  ..:|..||: .|:|||:.|.                ..:|:
Mouse   316 KYCSQECMQQAWDLYHSTECSL--GGLLLTLGVFCHVALRMTLL----------------ARFED 362

  Fly   343 IMNLSRKPEESENA-----PEYLRSLRMVSQLDQAIDEE-------------------LNYHILC 383
            :..:.|...:...:     ||....::......|...||                   .||:.:.
Mouse   363 VDRVVRMLCDEVGSTDTCLPESKNLVKAFDYTSQGESEEKSKIGEPPIPGCNVNGKYGSNYNAIF 427

  Fly   384 ANLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVM 448
            :      |..||:.:...|....:|.     :|||    ..||.|     |::....::..:...
Mouse   428 S------LLPHTEKHSPEHRFICAIS-----VSAL----CRQLKA-----DSVQAQTLKSPKLKA 472

  Fly   449 LQPEL------WQKP--RHLKRGQ---------LHNLSHSDPIT---AINL-----PYLSLCNHA 488
            :.|.|      |...  ||:.:.|         .|..|:...||   .|.|     |.:||.||:
Mouse   473 VTPGLCADLTVWGAAMLRHMLQLQCNAQAITSICHTGSNESIITNSRQIRLATGIFPVVSLLNHS 537

  Fly   489 CEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTD 553
            |.|:....|.|......||:.|.:|:||.:||..........:|...|.:.|.|:|.|..
Mouse   538 CRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCRCGA----- 597

  Fly   554 PDQNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCHELQHFAWYNEFLGL 618
                             |..|.|..|...    ||...|       |..|..|..   .|:.|..
Mouse   598 -----------------CHAETLRAAAAP----RWEAFC-------CKTCRALMQ---GNDVLSC 631

  Fly   619 IGSSADSS-KRQALFKAFDDLDKWLVDHHSLKRI---------------MAEELVTACFYEIDGG 667
            ...|..:| .|..|.....||.:.:.....|.|.               .||..::|      ..
Mouse   632 SNESCTNSVSRDQLVSRLQDLQQQVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSA------EH 690

  Fly   668 TSLDEFEYEDLARI-------------IRKQLEGIAAQCGDNSTEY------IARMTY------- 706
            |.|.|.| :.||:.             ::|.|:.:..:.|.:|.|.      :|::.:
Mouse   691 TVLGEIE-DGLAQAHATLGNWLKSAAHVQKSLQVVETRHGPSSVEIGHELFKLAQVLFNGLAVPE 754

  Fly   707 ----LW--DIIAQKKCRTDRKELLEMK 727
                :|  :.|....|..:.:|:.|::
Mouse   755 ALSAIWKAERILLVHCGPESEEVRELR 781

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.