Protein Alignment Smyd4-1 and Smyd4

DIOPT Version :10

• Sequence 1: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001099280.1
• Gene: Smyd4 / 287525
• RGDID: 1307369
• Length: 801
• Species: Rattus norvegicus
• Alignment Length: 871
• Identity: 189/871 - (21%)
• Similarity: 314/871 - (36%)
• Gaps: 259/871 - (29%)

  Fly    23 DEFETF--KSLASMPADILQIFQKLALDLLQD-------LEQPVDRKGCAERSKN---------- 68
            ||::::  :..|.:|..: |:....| :.|.|       |.||.|.....:.|.:
  Rat     6 DEWKSYLLEKWALLPKSV-QVTISTA-ETLSDIFLHSSSLLQPEDEMFLKQLSSSCSVEKDSGAP 68

  Fly    69 --LREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAY 131
              .|||||..|:|.       ..:.|..|||:.|..:....|::||.:|||..||...|.:....
  Rat    69 LFYREEGNKRFQEK-------EYMGAAVLYSKGVSHSRPNTEDISLCYANRSAALFHLGQHEACL 126

  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQL-----EDLK 191
            .|...|...||||||:.|:::|:..|   |..:..|:|....:..|:...:.:..|     :.|:
  Rat   127 KDIVRAGMHGYPERLQPKLMIRKTEC---LVNLGRLQEARQTISDLENSLTTKPTLMPSSHQILQ 188

  Fly   192 QKLELLKNQPREQETQGK---------VVDKSLGE-------------ILTDPGPRGRYMVAKEA 234
            :.::.||.:.:|:||..:         :.|.:|||             :.||| .:||::||.:.
  Rat   189 RNVQQLKMKIQEKETLPESFPAALTKALEDMALGEENKQISGASLSVSLCTDP-LKGRHLVATKD 252

  Fly   235 ISKGNVIFSERASCFV-------PLEQL-------------LICQQCAATLMSAPIPCPNCHQRV 279
            |..|.::..|.|...|       ||...             |.|.:|....: |.:||..| ...
  Rat   253 ILPGELLVKEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLRHTL-ATVPCGGC-SYA 315

  Fly   280 VYCSRKC-REAHSAIHKFECAAYRKDILRLLGI-SHLALRLLL--------TYIPYI-------- 326
            .|||::| ::|....|..||:.  ..:|..||: .|:|||:.|        ..|..|
  Rat   316 KYCSQECVQQAWDHYHSTECSL--GGLLLTLGVFCHVALRMTLLARFEDVDRVIRMICDKTGRKD 378

  Fly   327 --RPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQL 389
              .|..:::....|    ..|.....|.||.....:....:..:.:...|..|:
  Rat   379 TCLPESKDLVKTFG----YTNQGESEENSETCEPSIPGCNVNGKYENNYDAVLS----------- 428

  Fly   390 YLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPEL- 453
             |..||:.:...|....::.     :|||    ..||.|.......   .|::......:.|.|
  Rat   429 -LLPHTEKHSPEHKFICAVS-----VSAL----CRQLKATSLQAQT---TGLKSPRLKAVTPGLC 480

  Fly   454 -----W--QKPRHLKRGQLHNLSHSDPITAI---------------------NLPYLSLCNHACE 490
                 |  ...:|:.:.|    .::..||:|                     ..|.:||.||:|.
  Rat   481 TDLTVWGVAMLQHMLQLQ----CNAQAITSICYAGSKESIITNSRQVRLATGVFPVVSLLNHSCS 541

  Fly   491 PSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPD 555
            |:....|........||:.|.:|:||.:||..........:|...|.:.|.|:|:|
  Rat   542 PNTSVSFTSTVATIRAAQQIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCSC--------- 597

  Fly   556 QNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCH-ELQHFAWYNEFLGLI 619
                         |.|..|.|..|...    ||...|       |..|. .:|.    |:.|...
  Rat   598 -------------PACHAETLRAAVAP----RWEAFC-------CNTCRVPMQG----NDVLSCS 634

  Fly   620 GSSADSS-KRQALFKAFDDLDKWLVDHHSLKRIM------------------AEELVTA---CFY 662
            ..|..:| .|..|.....||.:.:   |:.::::                  ||..::|   ...
  Rat   635 NESCTNSVSRDRLVSRLQDLQQQV---HTAQKLLRSDRPEQAIQQLLECQRAAENFLSAEHTVLG 696

  Fly   663 EIDGG-----TSLDEFEYEDLARIIRKQLEGIAAQCGDNSTEY------IARMTY---------- 706
            ||:.|     .:|.  ::...|..::|.|:.:.|:.|.:|.|.      :|::.:
  Rat   697 EIEDGLAQAYATLG--DWRQSAAHVQKSLQVVEARHGPSSVEIGHELFKLAQVLFNGLAVPEALD 759

  Fly   707 -LWDIIAQK----KCRTDRKELLEMK 727
             :|.  |:|    .|..:..|:.|::
  Rat   760 AIWK--AEKILLVHCGPESDEVQELR 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	13/54 (24%)
		zf-MYND	258..298	CDD:460312	12/40 (30%)
		SET	<359..549	CDD:394802	43/218 (20%)
Smyd4	NP_001099280.1	3a0801s09	7..>211	CDD:273380	55/215 (26%)
		TPR repeat	68..96	CDD:276809	11/34 (32%)
		TPR repeat	101..136	CDD:276809	11/34 (32%)
		SET	239..>269	CDD:394802	11/30 (37%)
		zf-MYND	296..335	CDD:460312	12/40 (30%)
		SET_SMYD4	418..600	CDD:380934	44/231 (19%)
		TPR_12	661..728	CDD:315987	10/68 (15%)