DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and Smyd4

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001099280.1	Gene:	Smyd4 / 287525	RGDID:	1307369	Length:	801	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	189/871 - (21%)
Similarity:	314/871 - (36%)	Gaps:	259/871 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DEFETF--KSLASMPADILQIFQKLALDLLQD-------LEQPVDRKGCAERSKN---------- 68
            ||::::  :..|.:|..: |:....| :.|.|       |.||.|.....:.|.:
  Rat     6 DEWKSYLLEKWALLPKSV-QVTISTA-ETLSDIFLHSSSLLQPEDEMFLKQLSSSCSVEKDSGAP 68

  Fly    69 --LREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAY 131
              .|||||..|:|.       ..:.|..|||:.|..:....|::||.:|||..||...|.:....
  Rat    69 LFYREEGNKRFQEK-------EYMGAAVLYSKGVSHSRPNTEDISLCYANRSAALFHLGQHEACL 126

  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQL-----EDLK 191
            .|...|...||||||:.|:::|:..|   |..:..|:|....:..|:...:.:..|     :.|:
  Rat   127 KDIVRAGMHGYPERLQPKLMIRKTEC---LVNLGRLQEARQTISDLENSLTTKPTLMPSSHQILQ 188

  Fly   192 QKLELLKNQPREQETQGK---------VVDKSLGE-------------ILTDPGPRGRYMVAKEA 234
            :.::.||.:.:|:||..:         :.|.:|||             :.||| .:||::||.:.
  Rat   189 RNVQQLKMKIQEKETLPESFPAALTKALEDMALGEENKQISGASLSVSLCTDP-LKGRHLVATKD 252

  Fly   235 ISKGNVIFSERASCFV-------PLEQL-------------LICQQCAATLMSAPIPCPNCHQRV 279
            |..|.::..|.|...|       ||...             |.|.:|....: |.:||..| ...
  Rat   253 ILPGELLVKEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLRHTL-ATVPCGGC-SYA 315

  Fly   280 VYCSRKC-REAHSAIHKFECAAYRKDILRLLGI-SHLALRLLL--------TYIPYI-------- 326
            .|||::| ::|....|..||:.  ..:|..||: .|:|||:.|        ..|..|
  Rat   316 KYCSQECVQQAWDHYHSTECSL--GGLLLTLGVFCHVALRMTLLARFEDVDRVIRMICDKTGRKD 378

  Fly   327 --RPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQL 389
              .|..:::....|    ..|.....|.||.....:....:..:.:...|..|:
  Rat   379 TCLPESKDLVKTFG----YTNQGESEENSETCEPSIPGCNVNGKYENNYDAVLS----------- 428

  Fly   390 YLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPEL- 453
             |..||:.:...|....::.     :|||    ..||.|.......   .|::......:.|.|
  Rat   429 -LLPHTEKHSPEHKFICAVS-----VSAL----CRQLKATSLQAQT---TGLKSPRLKAVTPGLC 480

  Fly   454 -----W--QKPRHLKRGQLHNLSHSDPITAI---------------------NLPYLSLCNHACE 490
                 |  ...:|:.:.|    .::..||:|                     ..|.:||.||:|.
  Rat   481 TDLTVWGVAMLQHMLQLQ----CNAQAITSICYAGSKESIITNSRQVRLATGVFPVVSLLNHSCS 541

  Fly   491 PSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPD 555
            |:....|........||:.|.:|:||.:||..........:|...|.:.|.|:|:|
  Rat   542 PNTSVSFTSTVATIRAAQQIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCSC--------- 597

  Fly   556 QNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCH-ELQHFAWYNEFLGLI 619
                         |.|..|.|..|...    ||...|       |..|. .:|.    |:.|...
  Rat   598 -------------PACHAETLRAAVAP----RWEAFC-------CNTCRVPMQG----NDVLSCS 634

  Fly   620 GSSADSS-KRQALFKAFDDLDKWLVDHHSLKRIM------------------AEELVTA---CFY 662
            ..|..:| .|..|.....||.:.:   |:.::::                  ||..::|   ...
  Rat   635 NESCTNSVSRDRLVSRLQDLQQQV---HTAQKLLRSDRPEQAIQQLLECQRAAENFLSAEHTVLG 696

  Fly   663 EIDGG-----TSLDEFEYEDLARIIRKQLEGIAAQCGDNSTEY------IARMTY---------- 706
            ||:.|     .:|.  ::...|..::|.|:.:.|:.|.:|.|.      :|::.:
  Rat   697 EIEDGLAQAYATLG--DWRQSAAHVQKSLQVVEARHGPSSVEIGHELFKLAQVLFNGLAVPEALD 759

  Fly   707 -LWDIIAQK----KCRTDRKELLEMK 727
             :|.  |:|    .|..:..|:.|::
  Rat   760 AIWK--AEKILLVHCGPESDEVQELR 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	12/40 (30%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	24/107 (22%)
Smyd4	NP_001099280.1	TPR_11	68..132	CDD:290150	22/70 (31%)
		TPR repeat	68..96	CDD:276809	11/34 (32%)
		TPR repeat	101..136	CDD:276809	11/34 (32%)
		zf-MYND	296..335	CDD:280009	12/40 (30%)
		SET	<526..572	CDD:279228	15/45 (33%)
		TPR_12	692..>748	CDD:290160	12/57 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342706
Domainoid	1	1.000	59	1.000	Domainoid score	I10457
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107370
Panther	1	1.100	-	-	LDO	PTHR46165
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750