DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and AgaP_AGAP008839

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_319583.4	Gene:	AgaP_AGAP008839 / 1279815	VectorBaseID:	AGAP008839	Length:	650	Species:	Anopheles gambiae

Alignment Length:	664	Identity:	156/664 - (23%)
Similarity:	253/664 - (38%)	Gaps:	167/664 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TFSQQNELI--TLNENYKDEF-------ETFKSLASMPADILQIFQKLALDLLQDLEQPVDRKGC 62
            ||.:..|.:  :|::|..:||       |.|:.:..:         :..:|.|| |::..:.||
Mosquito     9 TFPRYCEAVRKSLDDNRFNEFAQLTSDEERFRFVNGL---------RKIVDELQ-LKREYNGKG- 62

  Fly    63 AERSKNLREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYY 127
            .|::..|:..||..|:   :....|:::...:.|   |...:..|:|.|:..|||..||    |:
Mosquito    63 MEQATALKTLGNKAFQ---AERWNDALVFYNKCY---VSTPKENVQEKSIILANRSAAL----YH 117

  Fly   128 REAYD----DCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQLE 188
            .|.||    |...||:..||.::.:|::.|:|.| :..||        :|...|:..::....|:
Mosquito   118 LEKYDLALRDIQRALDHQYPNQMMYKLVERKARC-FLAKK--------EYEAALECFKATVTALD 173

  Fly   189 D------LKQKLE---------LLKNQPREQETQ------------GKVVDKSLGEIL-TDPGP- 224
            |      .:||||         |.||...|::|:            .||.|..:.:.| .|..|
Mosquito   174 DSNLPLERRQKLERDAQIMINLLPKNIELEKKTKKKSSKADQSAPTTKVPDNFIEKALWFDESPD 238

  Fly   225 RGRYMVAKEAISKGNVIFSERASCFVPLEQLLI--CQQCAATLMSAPIPCPNCHQRVVYCSRKCR 287
            .||:......:....::..||....|.||...:  |..|... :|.||.||.|.. ||:||.:|.
Mosquito   239 EGRFARTNTDLKPNTILLLERPHVSVLLEDYSLDHCTHCFKR-VSVPIACPLCAD-VVFCSDECE 301

  Fly   288 -EAHSAIHKFECAAYRKDILRLL---GIS---HLALRLLL----TYIPYIRPHLQEMTSAKGMWE 341
             :|::..|::||.     .|.:|   |.|   |:|||::.    .|...::|.|..:|:
Mosquito   302 TKANATYHRYECG-----FLPILWGSGASITCHMALRMITQKSEEYFLKLKPELAGLTN------ 355

  Fly   342 EIMNLSRKPEESENAP--EYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSL 404
                     |:.:..|  :|.:..::|:.......|:.....|.|.||...|.     ...:.:.
Mosquito   356 ---------EQIDKLPVDDYRKVYKLVTHESTRSPEDFFQRTLMATLLNACLT-----LGGYGAC 406

  Fly   405 PASIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLS 469
            |..    |..|..|::.....|..|.|          |..|.:              |....::.
Mosquito   407 PQE----QNFIGGLLVHNLQLLQFNAH----------EVSEMI--------------RETAEDIG 443

  Fly   470 HSDPITAINLPYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSH 534
            .|..|.....|.|:|.||:|:|.:...:.|..|.....|:|.....:...|...:....:.:|..
Mosquito   444 KSTFIGGGLYPTLALFNHSCDPGVTRYYRGNQVCVRTVKNIPADSMVAENYGPLFTQVRRDERRD 508

  Fly   535 PLKAIYKFECTCAKC-------TRTDPDQNYLSFHRYRCEKPN-CRQEFLPDAKVQQNNLRWWLR 591
            .|...|:|.|.|..|       |..||     ...|:||:... |....|..|.|.
Mosquito   509 TLLHQYRFTCQCVPCVENWPLFTEMDP-----GVIRFRCDSGKICSNVLLIPAAVN--------- 559

  Fly   592 CNAEKPITCTVCHE 605
               :..:.||.|.|
Mosquito   560 ---DFMVKCTECGE 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	15/40 (38%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	15/78 (19%)
AgaP_AGAP008839	XP_319583.4	TPR_11	65..132	CDD:290150	20/76 (26%)
		TPR repeat	66..94	CDD:276809	6/33 (18%)
		TPR_11	104..167	CDD:290150	23/75 (31%)
		TPR repeat	104..134	CDD:276809	13/33 (39%)
		TPR repeat	142..166	CDD:276809	8/32 (25%)
		zf-MYND	274..313	CDD:280009	15/40 (38%)
		SET	<458..487	CDD:279228	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28135
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830