DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP010377

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_559081.3	Gene:	AgaP_AGAP010377 / 1272665	VectorBaseID:	AGAP010377	Length:	503	Species:	Anopheles gambiae

Alignment Length:	555	Identity:	130/555 - (23%)
Similarity:	194/555 - (34%)	Gaps:	156/555 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 RYMVAKEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPC------PNCHQRVVYCSRK 285
            |::||...|..|.:|.:|......|.....|  .|...|..|...|      |.|..    |||
Mosquito     1 RFLVANRDIKPGELILAEDPIVVGPYWDADI--SCLGCLGPASRTCRVCLKGPLCRD----CSR- 58

  Fly   286 CREAHSAIHKFECAAYRKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKP 350
                |..:   ||:.|.:       .|.|....|..:...|.|            ...:.|.|..
Mosquito    59 ----HDPV---ECSFYEQ-------ASKLNKNFLFDHFNIITP------------LRCLLLYRSD 97

  Fly   351 EESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQLII 415
            .:     :|...:.|.|..:...|.|: :||....:::..|.| .||        ..|:|
Mosquito    98 RD-----KYNEMMAMESHFESRRDTEI-WHIHNQYVVEPMLNE-KDF--------QQIDD----- 142

  Fly   416 SALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRG-------QLHNLSHSDP 473
                |...|:||      ..:.|: ::...|.:             ||       |::||:..
Mosquito   143 ----LTVTGELL------QRICGI-LDVNTFEI-------------RGNMDSQGVQMNNLARG-- 181

  Fly   474 ITAINLPYLSLCNHACEPSIRTKFDGCSVVN-YAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLK 537
                ..|..||..|.|:.:.....||.|.:. |::..|..||.::..||....::.:.| :|..|
Mosquito   182 ----LYPKTSLMTHNCQTNTLIAVDGMSKLRLYSSIGIKAGELLYYNYTRVLFSTFERQ-THLRK 241

  Fly   538 AIYKFECTCAKCTRTDPDQ---NYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPIT 599
            ..| |.|.||:|  :||.:   :..|.....|:...|  .|.|:..      :|          .
Mosquito   242 GKY-FICNCARC--SDPTELGTHLSSLKCTACDDGLC--VFHPETP------KW----------E 285

  Fly   600 CTVC-HELQHFAWYNEFL----GLIGSSADSSKRQALFKAFDDLDKWLVDHHSL----KRIMAEE 655
            |..| |:|.. .:.|:.:    ..|.|.|..|:.  |.|......|.|..||||    |:.:|.|
Mosquito   286 CLTCGHQLPR-EYVNQIMCEARDDISSCALDSRN--LEKVIGKHSKTLNPHHSLVLEAKQSLAGE 347

  Fly   656 LVTACF-YEIDG---GTSLDEFEY-EDLARIIRKQLEGIAAQCGDNSTEYIARMTYL----WDII 711
            |...|. |:|..   .....:.|. |::.:|:|....|::...|....||.|.:..|    .||.
Mosquito   348 LRNMCMSYDIHNVPRQALKRKLELCEEMLQILRVLDPGVSRLTGIALYEYHAALVDLSRRNHDIG 412

  Fly   712 AQKKCRTDRKELLE--------MKGKVDYLASEHR 738
            ..|     ..||||        :|..:..|..|||
Mosquito   413 EIK-----TPELLERLKLSEAALKEAIGMLVFEHR 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	10/45 (22%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	19/86 (22%)
AgaP_AGAP010377	XP_559081.3	SET	147..232	CDD:295368	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810