DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP011530

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_309979.4	Gene:	AgaP_AGAP011530 / 1271226	VectorBaseID:	AGAP011530	Length:	522	Species:	Anopheles gambiae

Alignment Length:	526	Identity:	110/526 - (20%)
Similarity:	176/526 - (33%)	Gaps:	161/526 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 GRYMVAKEAISKGNVIFSERASCFVPLEQLL--ICQQCAATLMSAP-IPCPNCHQRVVYCSRKCR 287
            ||::||...|..|.::..|......| .|:.  :|..|...|.... :.|..|...|  |.|.|:
Mosquito    50 GRFLVATRDIKAGEIVLKESPLVHGP-AQITGPVCVGCLQGLEEKKYLDCERCGWPV--CKRSCQ 111

  Fly   288 E--AHSAIHKFECAAYRKDILRLLGISHLALRLLLTYIPY-----IRP----HLQEMTSAKGMWE 341
            :  :|.|..||..|...|     :.|.|.       |:|:     :.|    .|.|...|:  ||
Mosquito   112 DSPSHQAECKFTIARGSK-----ISIQHF-------YVPHPTYQCLMPVRCLLLAESDPAR--WE 162

  Fly   342 EIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPA 406
            .::.|....||...:.::......|::|       :.....|.|
Mosquito   163 TLLKLESHEEERRGSEQWRNDREGVAKL-------IPRFFKCEN--------------------- 199

  Fly   407 SIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHS 471
               .|.   ...|||..|.:..|||             |..|.:|         ....::|::
Mosquito   200 ---KWD---EDEILRVVGIIQVNGH-------------EVPMTEP---------SSVAIYNMA-- 234

  Fly   472 DPITAINLPYLSLCNHACEPSIRTKF-DGCSVVNYAAKDILEGEEIFNCYT-MDYRNSLKLQRSH 534
                       |:..|:|.|::...| :...||.:|...|..|:.:..||| :.:....:|:.
Mosquito   235 -----------SMLEHSCRPNLAKSFTNRGEVVMWAPNPIRRGDRLSICYTDVLWTTGNRLEH-- 286

  Fly   535 PLKAIYKFECTCAKCTRTDPDQNYLSFHRYRC----EKPNCRQEFLPDAKVQQNNLRW---W--L 590
             |:....|.|.|.:|:.....:.|  |...||    :...|:...||     .:|.:|   |  |
Mosquito   287 -LQQTKMFRCECERCSDRTEYETY--FSAVRCSGFQKDSKCKGYLLP-----VDNAQWTGEWQCL 343

  Fly   591 RCNAEKPITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDDLDKWLVDHHSLKRIMAEE 655
            ||:.|.. ..|||..|:......|       :.:..:.....:......|||..:|   :.|.:
Mosquito   344 RCSKEVS-GATVCQILERARMDLE-------AMEKHREDHCNRYMKHYSKWLTANH---QYMVD- 396

  Fly   656 LVTACFYEIDGG---TSLDEFEYE----------DLARIIRK--------------QLEGIAAQC 693
             |.....::.||   .::.:..||          ||..:..|              :|....|:.
Mosquito   397 -VKISLSQVIGGKNPEAIKKIPYEKLMNKIKICQDLIALFEKICPAEARAFGATRFELHAALAEL 460

  Fly   694 GDNSTE 699
            |..|||
Mosquito   461 GRRSTE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	13/42 (31%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	16/80 (20%)
AgaP_AGAP011530	XP_309979.4	zf-MYND	2..38	CDD:280009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810