DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP011232

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_309411.4	Gene:	AgaP_AGAP011232 / 1270692	VectorBaseID:	AGAP011232	Length:	434	Species:	Anopheles gambiae

Alignment Length:	492	Identity:	108/492 - (21%)
Similarity:	187/492 - (38%)	Gaps:	115/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RSKNLREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYRE 129
            |:..||.:||.:|.:     .:...:.|...|:|::..:....|..::.:.||.....:.|.|.:
Mosquito    21 RAAVLRTKGNELFHK-----RERKYIAATVYYNESIAHSPKGSEVRAIGYGNRAAVCLQLGRYED 80

  Fly   130 AYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESFEQQLEDLKQKL 194
            ...:...|.|..||..|..|:.||:. .|..::  ||.|....:.....:.|  :|..::||
Mosquito    81 CLANVRLARESNYPAALMGKLTMREV-AAQSMQ--ASAEAARRFADDPMVPE--DQHAQELK--- 137

  Fly   195 ELLKNQPREQETQGKVVDKSLGEILTDPGPRGRYMVAKEAISKGNVIFSERASCFVPLEQL--LI 257
               .:.|.......:|.|..    |.:....||::||...:..|:|:..|:....|..:.:  :.
Mosquito   138 ---LSYPAHPTVPQRVADLQ----LCNNQQYGRHVVATRQLRVGDVVMVEKPYATVLSDHMKRVR 195

  Fly   258 CQQCAATLMSAPIPCPNCHQRVVYCSRKC-REAHSAIHKFECAAYRKDILRLLGISHLALRLLLT 321
            |..|.|......|||..| ...:|||:|| |.|....|::||.....  :|.:|..:|||.:...
Mosquito   196 CAFCHAEEPFLLIPCEEC-TIAMYCSQKCLRAAWQQYHRYECPILND--MRTIGTEYLALAVRTV 257

  Fly   322 YIPY---------IRPHLQEM--------------TSAKGMWEEIMNLS---RKPEESENAPEYL 360
            .|..         :|.||..:              .|.:.::|.:.:|:   ||....:.|...|
Mosquito   258 AIALASFDHDLEALRAHLSHLDVSKVNAFEMDWRAASPRTVYETVYSLATNQRKRARKDFALNVL 322

  Fly   361 RSL---RMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRF 422
            .::   :::.:...|........||...||.|.|          |.|.::|.:.|.:
Mosquito   323 VAMITHKLLLKRTPAAQVCGADPILRKTLLNLLL----------HHLQSTIVNHQFL-------- 369

  Fly   423 AGQLLANGHVGDALLGVGM-EPKEFVMLQPELWQKPRHLKRGQLHNLSHSDPITAINLPYLSLCN 486
                    |..|.|....: ||.|:.:                            ...|.||:.|
Mosquito   370 --------HYMDYLAEQDVYEPDEYAI----------------------------ACFPLLSMLN 398

  Fly   487 HACEPSIR--TKFDG-CSVVNYAAKDILEGEEIFNCY 520
            |:|.|:::  |..|| |::|  ..:.|.:|.::|:.|
Mosquito   399 HSCAPNVKRITMRDGRCALV--VTRQIADGGQLFDHY 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	15/40 (38%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	16/77 (21%)
AgaP_AGAP011232	XP_309411.4	TPR_11	21..90	CDD:290150	15/73 (21%)
		zf-MYND	196..236	CDD:280009	15/40 (38%)
		SET	341..433	CDD:279228	31/147 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820