DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-1 and AgaP_AGAP009448

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_307865.2	Gene:	AgaP_AGAP009448 / 1269246	VectorBaseID:	AGAP009448	Length:	561	Species:	Anopheles gambiae

Alignment Length:	568	Identity:	129/568 - (22%)
Similarity:	219/568 - (38%)	Gaps:	122/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LASMP-ADILQIFQKLALDLLQDLEQPVDRKGCAERSKNLREEGNLMFKESASGSSKDSVLKACR 94
            |:..| .:.||:..::..|               |::..||.|||.|......     .:.:|.:
Mosquito    12 LSEFPFREFLQLHNEVKYD---------------EQAAKLRTEGNKMVDPKVK-----RLYEAVK 56

  Fly    95 LYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAW 159
            ||:|::...:....|.|||:|||.:...:...|.|...:...|.|..||.||..|:..|:.....
Mosquito    57 LYNESITYTKPGSTERSLAYANRSVVCLQMHRYEECLANIRLAREANYPARLADKLDKREEQAKE 121

  Fly   160 KLKKIASLEEHLDYLGQLQLKESFEQQLEDLKQKLELLKNQPREQETQGKVVDKSLGEILTDPGP 224
            :|.|....::..|. .:.:|..||... |::......|:.|..||
Mosquito   122 ELAKSNEKQKKKDD-PKPELPLSFPGH-ENMPHVANCLQLQQNEQ-------------------- 164

  Fly   225 RGRYMVAKEAISKGNVIFSERASCFV-----PLEQLLICQQCAATLMSAPIPCPNCHQRVVYCSR 284
            .||::|....:..|:|:..:  :.||     ||..:. |..|.|......|||..| ..|:|||.
Mosquito   165 YGRHVVTTRRLKVGDVVMLD--TPFVKTLHDPLRHVR-CDFCHAERPFTLIPCEGC-TWVMYCSA 225

  Fly   285 KC-REAHSAIHKFECAAYRKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSR 348
            :| .:|:|..|::||...| |:.|:.|      :..:|.:       :.:.||.|.:::
Mosquito   226 ECLGKAYSQYHRYECGVMR-DLWRVAG------KCPMTAV-------RTVASAFGTFDD------ 270

  Fly   349 KPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHT--DFYDQFHSLPASIED- 410
                   .|:.|:     :.|| |:||..      .|...:..:..|  |.|...|.|..:.|.
Mosquito   271 -------DPDALQ-----AHLD-ALDEPQ------VNGFTMDWRTATPKDVYSTVHVLSTNQERR 316

  Fly   411 --WQLIISALILRFAGQLL-----------ANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKR 462
              .||:....:.....:|:           |...:|..|..:.:...:.:.:..:......|  |
Mosquito   317 PFMQLVFMVYLAIIIHKLMLERTELGPRSRAKPSIGKLLFDLILRHVQVMRINRQFLSFYEH--R 379

  Fly   463 GQLHNLSHSDPITAINLPYLSLCNHACEPSIRTKF--DG-CSVVNYAAKDILEGEEIFNCYTMDY 524
            .........:..||. .|.:|:.||:|..::|...  || |:::  ..:.|..||::|:.|.:.:
Mosquito   380 PDRQRFQAKEYGTAC-YPLVSMFNHSCASNVRRLILRDGRCAMI--VIRPIGPGEQLFDSYGLHH 441

  Fly   525 RNSLKLQRSHPLK---AIYKFECTCAKCTRTDPDQNYLSFHRYRCEKP 569
               ...:|||..|   .::.|||.|..|....|..|.:...:.|...|
Mosquito   442 ---FSFERSHRQKGTFVMFNFECCCEACALNYPTLNQIVNQQSRAPMP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	15/40 (38%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	18/81 (22%)
AgaP_AGAP009448	XP_307865.2	TPR_11	32..103	CDD:290150	21/75 (28%)
		zf-MYND	200..240	CDD:280009	15/40 (38%)
		SET	<364..438	CDD:279228	17/78 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D30377at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820