back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-1 and SMYD4

DIOPT Version :9

Sequence 1:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	871	Identity:	207/871 - (23%)
Similarity:	320/871 - (36%)	Gaps:	256/871 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DEFETF--KSLASMPADILQIFQKLALDLLQD-------LEQPVDRKGCAERSKN---------- 68
            ||::::  :..||:|..: |:....| :.|:|       |.||.|.......||.
Human     6 DEWKSYLLQKWASLPTSV-QVTISTA-ETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAP 68

  Fly    69 --LREEGNLMFKESASGSSKDSVLKACRLYSEAVFEAENAVEELSLAFANRGIALQEYGYYREAY 131
              .|||||..|:|      || ...|..|||:.|..:....|::||..|||..||...|.|....
Human    69 LFYREEGNKKFQE------KD-YTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCL 126

  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQ------------LKESFE 184
            .|.:.|...||||||:.|:::|:|.|   |..:..|:|....:..|:            |.::.:
Human   127 KDINRAQTHGYPERLQPKIMLRKAEC---LVALGRLQEASQTISDLERNFTATPALADVLPQTLQ 188

  Fly   185 QQLEDLKQKLE----LLKNQP------------REQETQGKVVDKSLGEILTDPGPRGRYMVAKE 233
            :.|..||.|::    |.::.|            ||:..|......|:| :..|| .:||.:||.:
Human   189 RNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIG-LCVDP-LKGRCLVATK 251

  Fly   234 AISKGNVIFSERASCFV--------PLEQL------------LICQQCAATLMSAPIPCPNCHQR 278
            .|..|.::..|.|...|        |...|            |.|.:|....: |.:||..| ..
Human   252 DILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTL-ATVPCDGC-SY 314

  Fly   279 VVYCSRKC-REAHSAIHKFECAAYRKDILRLLGI-SHLALRL-LLTYIPYIRPHLQEMTSAKGMW 340
            ..|||::| ::|....|:.||..  ..:|..||: .|:|||| ||.....:|..:.::.
Human   315 AKYCSQECLQQAWELYHRTECPL--GGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLC------ 371

  Fly   341 EEIMNLSRKPEESENAPEYLRSLRMVSQLDQAIDE---------------------ELNYHILCA 384
            ::|.|......||.|         .|..|:..:.|                     |.||:.: .
Human   372 DKISNKDICLPESNN---------QVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAV-F 426

  Fly   385 NLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRF-AGQLLA---NGHVGDALLGVGMEPKE 445
            |||     .||:.:...|....:     |.:|||..:. |..|.|   ...|..:.|...:.|:
Human   427 NLL-----PHTENHSPEHKFLCA-----LCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPE- 480

  Fly   446 FVMLQPE--LW--QKPRHLKRGQ-----LHNLSHSDP-------------ITAINLPYLSLCNHA 488
               |.|:  :|  ...||:.:.|     :..:.|:.|             .|.| .|.:||.||:
Human   481 ---LCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGI-FPVISLLNHS 541

  Fly   489 CEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTD 553
            |.|:....|........|::.|.:|:||.:||..........:|...|::.|.|:|.|..| :|:
Human   542 CSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC-QTE 605

  Fly   554 PDQNYLSFHR------------------------YRCEKPNCR-------------QEFLPDAKV 581
            .       ||                        .||...:|.             |:.....:|
Human   606 A-------HRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRV 663

  Fly   582 QQNNLR-WWLRCNAEKPITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDDLDKWLVDH 645
            .|..|| ..|....::...|.  .:.:.|.|...  .::|..||     .|.:|...|..|....
Human   664 AQKLLRDGELERAVQRLSGCQ--RDAESFLWAEH--AVVGEIAD-----GLARACAALGDWQKSA 719

  Fly   646 HSLKRIMAEELVTACFYEIDGGTSLDEFEYE--DLARI-------------IRKQLEGIAAQCG- 694
            ..|:|       :....|:..|.|..|..:|  .||:|             |:|..|.::..||
Human   720 THLQR-------SLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGP 777

  Fly   695 -DNSTEYIARMTYLWDIIAQKKCRTD 719
             |:..:.:.:|         |.|..|
Human   778 WDDEIQELQKM---------KSCLLD 794

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.