Protein Alignment Nt5c and NT5DC2

DIOPT Version :10

• Sequence 1: NP_610499.2
• Gene: Nt5c / 35984
• FlyBaseID: FBgn0033426
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001127703.1
• Gene: NT5DC2 / 64943
• HGNCID: 25717
• Length: 557
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 237/551 - (43%)
• Similarity: 332/551 - (60%)
• Gaps: 51/551 - (9%)

  Fly    19 LRAGGVLRSW-------DPISSSLSPSPC----KPNYSFEARAFASDAGASAPAATAQISHP--K 70
            |||..  |.|       .|.::|.||| |    .|............|.|.||.:.|.:|..  .
Human     6 LRAAA--RRWLLCGGHGGPRAASSSPS-CPGCGPPGPGAHCPGVPRSAPAQAPTSGADLSAHLWA 67

  Fly    71 TVSDFQKL-HEATKKKFQSKKLPSDV----HPDAVFACNELDLSEVQVYGFDYDYTLACYKPILE 130
            ...|.::| |:.         ||.:|    :|.|::|.||:.|.:|:|||||||||||.|...|.
Human    68 RYQDMRRLVHDL---------LPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALH 123

  Fly   131 DLLYNLAREMLVKRFRYPEDILQLEYEPNFAVRGLHYDVEKGLLVKLDSFLQLQLGSVYRGRTKV 195
            ..:::.||::|::.::|||.|.:.:|.|:||:||||||::|.||:|:|:|..:|||:.|||...|
Human   124 PEIFSTARDILIEHYKYPEGIRKYDYNPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPV 188

  Fly   196 EADEVLKLY----HNRLLPIA--YVEGPNNSYRHNTNSKMVQLADLFSVPEMCLLCNVIEYFERN 254
            ..:||::||    |..|..::  |.:||:          :.|..|:||:|||.||..|::||..:
Human   189 PDEEVIELYGGTQHIPLYQMSGFYGKGPS----------IKQFMDIFSLPEMALLSCVVDYFLGH 243

  Fly   255 RIDYNPEIVFHDTRTAMGSCH--PIMHGKVMRNTEKYIERNPKLVKFFEKLQQAGKNLFLVTNSP 317
            .::::...::.|...|:...|  .:|:..:.::.||||.|..:......:|...||.|||:||||
Human   244 SLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSP 308

  Fly   318 YSFVNCGMSFLVGANWRDFFDVVIVQARKPKFFTDESRPIRLFDERTQSHLWDRVFKLEKGKIYY 382
            :|||:.||..:||.:||..||||||||.||.||||..:|.|..||: .|..|||:.:|||||||.
Human   309 FSFVDKGMRHMVGPDWRQLFDVVIVQADKPSFFTDRRKPFRKLDEK-GSLQWDRITRLEKGKIYR 372

  Fly   383 EGSVRQLQELKGWRGHSVLYFGDHPYSDLADVTLKHSWRTGAIISELAHEIKTLNRKDFKMSANW 447
            :|::.....|..|||..|||||||.||||||:.|:|.|||||||.||..||:.:|.:.:..|..|
Human   373 QGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTW 437

  Fly   448 LQMLTQLIEDTQD-DDSEAAQICLKEWMEERDQLRNKTKNVFNEQFGSVFRTYHNPTYFSRRLFR 511
            .|.||.|:|..|. .|:|:.|: |..||:||.:||..||.:||.||||:|||:||||||||||.|
Human   438 QQALTGLLERMQTYQDAESRQV-LAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVR 501

  Fly   512 FADIYTSDITNLLKFSTTHTFYPRRGVMPHE 542
            |:|:|.:.::.||.:....||||||..:.||
Human   502 FSDLYMASLSCLLNYRVDFTFYPRRTPLQHE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nt5c	NP_610499.2	5_nucleotid	108..544	CDD:461733	208/444 (47%)
NT5DC2	NP_001127703.1	5_nucleotid	101..534	CDD:461733	208/444 (47%)