DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp6 and Alp4

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	203/532 - (38%)
Similarity:	283/532 - (53%)	Gaps:	75/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GRSFDAESHPIKYAEEQQTQYW--VDKAQAKLLSKLAE--QESATTNKAKNVILFLGDGMSVHTV 88
            |..||..    |..|.:..::|  |...|.:...|.|:  :|.:...||:|:|:|:||||.:.|:
  Fly    40 GPQFDVG----KTKEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTI 100

  Fly    89 TATRNLLGD-------SAEQVYFEGFPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVN 146
            :|.|...|.       ..|.:.|:.||.||::|||.|::||.|||.||||...|.|.:||.||::
  Fly   101 SAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMD 165

  Fly   147 ANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEVAN 211
            |..|:.:     .::.||.|:..|||..||..|:|||.|:|||:||..||||.||:||.|.||
  Fly   166 ATRSKKN-----GQQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEV-- 223

  Fly   212 RECDPEQT----IDIARQLVEQPVGQQLKVILGGGRK-----NFIDATVNDEEGYPGK----RTD 263
                |.::    :||||||||...|.:..||||||..     |..:......|| |.:    |.|
  Fly   224 ----PAESVGFHVDIARQLVENAPGNRFNVILGGGMSPMGILNASEVKTTIFEG-PTETICTRGD 283

  Fly   264 GRHLIRSWLDQKKEANVSAKYVWSRKGLSLVDLENTDYLLGLFANDHLPYNGDRDRKRSQLADPS 328
            .|:|...||.......|....|.:||.|..|:::..|:|:|||.|:|:.|:..|     :..:||
  Fly   284 NRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAR-----EAGEPS 343

  Fly   329 LSELTEAAITVLSRNDK--GFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDT 391
            |.|:||.|:.:|.|.|:  ||.|.|||.|||..||..:|:.:|.:..||..|:|.|...|..|:|
  Fly   344 LQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDET 408

  Fly   392 LIVVTADHAHVMSINGYPYRDQEITGLAQLADDNLP--YTILSYANGPGYYS------------- 441
            ||:|||||:|.::.|||..|..:|.|.|...:.|.|  |..:||||||||:.
  Fly   409 LILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSN 473

  Fly   442 -----GYNRAEGRALLKEKLVADSDYQYPTLAPLDAETHGGDDVAVYASGPYAQYFSGNYEQSNI 501
                 .:..||.||.        ..|::....|...|||||:||||:|.||.:....|.:||:.:
  Fly   474 MWMPLKHFTAEERAA--------PTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYL 530

  Fly   502 PALMARAAGIGP 513
            ..:|:.|..:||
  Fly   531 AYVMSYAGCLGP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	189/480 (39%)
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	193/498 (39%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	188/480 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466683
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900