DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp6 and Alp8

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	212/532 - (39%)
Similarity:	304/532 - (57%)	Gaps:	34/532 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RRFILLLVLAVCLSGSA-------------SGQRDHPRGRSFDAESHPIKYAEEQQTQYWVDKAQ 54
            |:.:|.::|.:.|:|:|             :||..:....|.|..:......||...|||.:.|.
  Fly     6 RQLVLPILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIAD 70

  Fly    55 AKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNL----LGDSAEQ--VYFEGFPYTGLS 113
            .::..:| :.....:.||||:|:||||||.:.||.|.|.|    .|::.|:  :.||.|||||||
  Fly    71 EEITKRL-QLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLS 134

  Fly   114 KTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDA 178
            :|||.|.||.||||||||||.|||.|...|||:|.|...:|..:.:..:|:.|||.|||.|||..
  Fly   135 RTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKST 199

  Fly   179 GLVTTARVTHASPAGVYAHIADRNWENDWEVANRECDPEQTIDIARQLVEQPVGQQLKVILGGGR 243
            |:|||..:|||||:|.||..|:|.||.|.:|.:...|....||:|.|||.|..|:..:|:.|||.
  Fly   200 GIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGM 264

  Fly   244 KNFIDATVNDEEGYPGKRTDGRHLIRSWLDQKKEANVSAKYVWSRKGLSLVDLENTDYLLGLFAN 308
            ..|:..::.|..|.||:|:||.:|:..|    :..:.....|.:|..|..:::.....::|||.:
  Fly   265 GKFLPNSIVDSHGNPGERSDGVNLLSRW----QGLHDGGVLVTNRNQLLKLNVSAVSSVIGLFQS 325

  Fly   309 DHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRN-DKGFFLFVEGARIDMAHHDTFAKRSLEDT 372
            ..:.::.:.|    ....|:||||||..|..||:| :.|:|.|:||..||..:|.|.|..:|::.
  Fly   326 KLMNFHLEAD----DTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEA 386

  Fly   373 AEFARAVQKARELTSEDDTLIVVTADHAHVMSINGYPYRDQEITGLAQLADD--NLPYTILSYAN 435
            .||.:|:|.||::|..:||||||||||.|.:||.|||.|...|.|:.|...|  .:.|::|:||.
  Fly   387 LEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAA 451

  Fly   436 GPGYYSGYNRAEGRALLKEKLVADSDYQYPTLAPLDAETHGGDDVAVYASGPYAQYFSGNYEQSN 500
            ||..|...|   |:.:..:.::...|...|:..|.|...|.|:||.::||||.:..|:|..:||.
  Fly   452 GPNQYLDEN---GQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQST 513

  Fly   501 IPALMARAAGIG 512
            ||.|||.||.||
  Fly   514 IPHLMAYAACIG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	192/447 (43%)
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	191/447 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466661
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900