Protein Alignment Alp6 and ALPG

DIOPT Version :10

• Sequence 1: NP_610496.1
• Gene: Alp6 / 35981
• FlyBaseID: FBgn0033423
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_112603.2
• Gene: ALPG / 251
• HGNCID: 441
• Length: 532
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 215/491 - (43%)
• Similarity: 284/491 - (57%)
• Gaps: 42/491 - (8%)

  Fly    42 EEQQTQYWVDKAQAKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNLLGDSAEQ----- 101
            ||:...:| ::..|:.|....:.:.|.| .|||:|:||||||.|.||||.|.|.|...::
Human    24 EEENPDFW-NRQAAEALGAAKKLQPAQT-AAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPET 86

  Fly   102 -VYFEGFPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVL 165
             :..:.|||..|||||.|::.|.||..||||||.|||.|:.|||::|......|:.....|  |:
Human    87 FLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNE--VI 149

  Fly   166 SIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEV---ANRE-CDPEQTIDIARQL 226
            |:.:.|:.|||..|:|||.||.||||||.|||..:|||.:|.:|   |.:| |.     |||.||
Human   150 SVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQ-----DIATQL 209

  Fly   227 VEQPVGQQLKVILGGGRKNFIDATVNDEEGYP------GKRTDGRHLIRSWLDQKKEANVSAKYV 285
            :.   ...:.||||||||........|.| ||      |.|.||::|::.||.:.:    .|:||
Human   210 IS---NMDIDVILGGGRKYMFPMGTPDPE-YPDDYSQGGTRLDGKNLVQEWLAKHQ----GARYV 266

  Fly   286 WSRKGLSLVDLE-NTDYLLGLFANDHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRNDKGFFL 349
            |:|..|....|: :..:|:|||....:.|...||    ...||||.|:||||:.:||||.:||||
Human   267 WNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD----STLDPSLMEMTEAALLLLSRNPRGFFL 327

  Fly   350 FVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDTLIVVTADHAHVMSINGYPYRDQE 414
            ||||.|||..||::.|.|:|.:|..|..|:::|.:||||:|||.:|||||:||.|..|||.|...
Human   328 FVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSS 392

  Fly   415 ITGLAQ-LADDNLPYTILSYANGPGYYSGYNRAEGRALLKEKLVADSDYQYPTLAPLDAETHGGD 478
            |.|||. .|.|...||:|.|.|||||..   :...|..:.|......:|:..:..|||.|||.|:
Human   393 IFGLAPGKARDRKAYTVLLYGNGPGYVL---KDGARPDVTESESGSPEYRQQSAVPLDGETHAGE 454

  Fly   479 DVAVYASGPYAQYFSGNYEQSNIPALMARAAGIGPY 514
            ||||:|.||.|....|..||:.|..:||.||.:.||
Human   455 DVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	alkPPc	73..512	CDD:214515	205/456 (45%)
ALPG	NP_112603.2	Alk_phosphatase	52..487	CDD:395188	206/456 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..443		3/20 (15%)