DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp6 and ALPL

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_000469.3	Gene:	ALPL / 249	HGNCID:	438	Length:	524	Species:	Homo sapiens

Alignment Length:	523	Identity:	224/523 - (42%)
Similarity:	289/523 - (55%)	Gaps:	54/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLVLAVCLSGSASGQRDHPRGRSFDAESHPIKYAEEQQTQYWVDKAQAKLLSKLAEQESATTNK 71
            |:|.:..||:.|...::                   |:..:||.|:||..|...| |.:...||.
Human     6 LVLAIGTCLTNSLVPEK-------------------EKDPKYWRDQAQETLKYAL-ELQKLNTNV 50

  Fly    72 AKNVILFLGDGMSVHTVTATRNLLG----DSAEQVYFE--GFPYTGLSKTYCVNRQVADSACTAT 130
            |||||:||||||.|.||||.|.|.|    :..|:...|  .||:..|||||..|.||.|||.|||
Human    51 AKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTAT 115

  Fly   131 AYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASPAGVY 195
            |||.|||||.||:||:|...|..|:.....|  |.||..||:.|||..|:|||.||.||:|:..|
Human   116 AYLCGVKANEGTVGVSAATERSRCNTTQGNE--VTSILRWAKDAGKSVGIVTTTRVNHATPSAAY 178

  Fly   196 AHIADRNWENDWEVANRECDPEQTI----DIARQLVEQPVGQQLKVILGGGR-----KNFIDATV 251
            ||.|||:|.:|     .|..||...    |||.||:...  :.:.||:||||     ||..|...
Human   179 AHSADRDWYSD-----NEMPPEALSQGCKDIAYQLMHNI--RDIDVIMGGGRKYMYPKNKTDVEY 236

  Fly   252 NDEEGYPGKRTDGRHLIRSWLDQKKEANVSAKYVWSRKGLSLVDLENTDYLLGLFANDHLPYNGD 316
            ..:|...|.|.||..|:.:|...|.....| .::|:|..|..:|..|.|||||||....:.|
Human   237 ESDEKARGTRLDGLDLVDTWKSFKPRYKHS-HFIWNRTELLTLDPHNVDYLLGLFEPGDMQY--- 297

  Fly   317 RDRKRSQLADPSLSELTEAAITVLSRNDKGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQK 381
             :..|:.:.||||||:...||.:|.:|.|||||.|||.|||..||:..||::|.:..|..||:.:
Human   298 -ELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQ 361

  Fly   382 ARELTSEDDTLIVVTADHAHVMSINGYPYRDQEITGLA-QLAD-DNLPYTILSYANGPGYYSGYN 444
            |..|||.:|||.||||||:||.:..||..|...|.||| .|:| |..|:|.:.|.|||||.....
Human   362 AGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGG 426

  Fly   445 RAEGRALLKEKLVADSDYQYPTLAPLDAETHGGDDVAVYASGPYAQYFSGNYEQSNIPALMARAA 509
            ..|..:::.   .|.::||..:..||..|||||:||||::.||.|....|.:||:.:|.:||.||
Human   427 ERENVSMVD---YAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAA 488

  Fly   510 GIG 512
            .||
Human   489 CIG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	206/455 (45%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	206/455 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157456
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910