DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp6 and ALPI

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	494	Identity:	218/494 - (44%)
Similarity:	279/494 - (56%)	Gaps:	46/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AEEQQTQYWVDKAQAKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNLLGDS------A 99
            |||:...:|  ..||......|::.......|||:|||||||:.|.||||||.|.|..      .
Human    23 AEEENPAFW--NRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPE 85

  Fly   100 EQVYFEGFPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAANEEDRV 164
            ..:..:.|||..|||||.|:|||.|||.||||||.|||||:.|||::|......|:.....|  |
Human    86 TPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNE--V 148

  Fly   165 LSIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEV---ANRE-CDPEQTIDIARQ 225
            :|:.:.|:.|||..|:|||.||.||||||.|||..:|||.:|.::   |.:| |.     |||.|
Human   149 ISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQ-----DIATQ 208

  Fly   226 LVEQPVGQQLKVILGGGRKNFIDATVNDEEGYP------GKRTDGRHLIRSWLDQKKEANVSAKY 284
            |:.   ...:.||||||||........|.| ||      |.|.||::|::.||.:.:    .|.|
Human   209 LIS---NMDIDVILGGGRKYMFPMGTPDPE-YPADASQNGIRLDGKNLVQEWLAKHQ----GAWY 265

  Fly   285 VWSRKGLSLVDL-ENTDYLLGLFANDHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRNDKGFF 348
            ||:|..|....| ::..:|:|||......|...||    ...||||.|:||||:.:||||.:||:
Human   266 VWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD----PTLDPSLMEMTEAALRLLSRNPRGFY 326

  Fly   349 LFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDTLIVVTADHAHVMSINGYPYRDQ 413
            |||||.|||..||:..|.::|.:...|..|:::|.:||||:|||.:|||||:||.|..||..|..
Human   327 LFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGS 391

  Fly   414 EITGLA-QLADDNLPYTILSYANGPGYY--SGYNRAEGRALLKEKLVADSDYQYPTLAPLDAETH 475
            .|.||| ..|.|:..||.:.|.|||||.  ||.     |..:.|......|||.....||.:|||
Human   392 SIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGV-----RPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   476 GGDDVAVYASGPYAQYFSGNYEQSNIPALMARAAGIGPY 514
            ||:||||:|.||.|....|..|||.:..:||.||.:.||
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	209/458 (46%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	209/458 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157469
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8508
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940