Protein Alignment Alp6 and ALPI

DIOPT Version :10

• Sequence 1: NP_610496.1
• Gene: Alp6 / 35981
• FlyBaseID: FBgn0033423
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 218/494 - (44%)
• Similarity: 279/494 - (56%)
• Gaps: 46/494 - (9%)

  Fly    41 AEEQQTQYWVDKAQAKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNLLGDS------A 99
            |||:...:|  ..||......|::.......|||:|||||||:.|.||||||.|.|..      .
Human    23 AEEENPAFW--NRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPE 85

  Fly   100 EQVYFEGFPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAANEEDRV 164
            ..:..:.|||..|||||.|:|||.|||.||||||.|||||:.|||::|......|:.....|  |
Human    86 TPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNE--V 148

  Fly   165 LSIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEV---ANRE-CDPEQTIDIARQ 225
            :|:.:.|:.|||..|:|||.||.||||||.|||..:|||.:|.::   |.:| |.     |||.|
Human   149 ISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQ-----DIATQ 208

  Fly   226 LVEQPVGQQLKVILGGGRKNFIDATVNDEEGYP------GKRTDGRHLIRSWLDQKKEANVSAKY 284
            |:.   ...:.||||||||........|.| ||      |.|.||::|::.||.:.:    .|.|
Human   209 LIS---NMDIDVILGGGRKYMFPMGTPDPE-YPADASQNGIRLDGKNLVQEWLAKHQ----GAWY 265

  Fly   285 VWSRKGLSLVDL-ENTDYLLGLFANDHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRNDKGFF 348
            ||:|..|....| ::..:|:|||......|...||    ...||||.|:||||:.:||||.:||:
Human   266 VWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD----PTLDPSLMEMTEAALRLLSRNPRGFY 326

  Fly   349 LFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDTLIVVTADHAHVMSINGYPYRDQ 413
            |||||.|||..||:..|.::|.:...|..|:::|.:||||:|||.:|||||:||.|..||..|..
Human   327 LFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGS 391

  Fly   414 EITGLA-QLADDNLPYTILSYANGPGYY--SGYNRAEGRALLKEKLVADSDYQYPTLAPLDAETH 475
            .|.||| ..|.|:..||.:.|.|||||.  ||.     |..:.|......|||.....||.:|||
Human   392 SIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGV-----RPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   476 GGDDVAVYASGPYAQYFSGNYEQSNIPALMARAAGIGPY 514
            ||:||||:|.||.|....|..|||.:..:||.||.:.||
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	alkPPc	73..512	CDD:214515	208/458 (45%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:395188	209/458 (46%)