DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp6 and Akp3

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	497	Identity:	220/497 - (44%)
Similarity:	277/497 - (55%)	Gaps:	55/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EEQQTQYWVDKAQAKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNLLGDSAEQVYFEG 106
            ||:...:|..|| |:.|....:.:...|: |||:|:||||||.|.||||||.|.|.      .||
Mouse    24 EEENPAFWNKKA-AEALDAAKKLQPIQTS-AKNLIIFLGDGMGVPTVTATRILKGQ------LEG 80

  Fly   107 ------------FPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAAN 159
                        |||..|||||.|:|||.|||.||||||.|||.||.||||:|......|:....
Mouse    81 HLGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFG 145

  Fly   160 EEDRVLSIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEV---ANRE-CDPEQTI 220
            .|  |.|:.:.|:.|||..|:|||.||.||||:|.|.|..:|||..|.::   |.|| |.
Mouse   146 NE--VFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDADMPASALREGCK----- 203

  Fly   221 DIARQLVEQPVGQQLKVILGGGRKNFIDATVNDEEGYP------GKRTDGRHLIRSWLDQKKEAN 279
            |||.||:.   ...:.||||||||....|...|.| ||      |.|.|||:|::.||.:.:
Mouse   204 DIATQLIS---NMDINVILGGGRKYMFPAGTPDPE-YPNDANETGTRLDGRNLVQEWLSKHQ--- 261

  Fly   280 VSAKYVWSRKGL-SLVDLENTDYLLGLFANDHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRN 343
             .::|||:|:.| ......:..||:|||.    |.:...|.:|..|.||||.::||||:.|||||
Mouse   262 -GSQYVWNREQLIQKAQDPSVTYLMGLFE----PVDTKFDIQRDPLMDPSLKDMTEAAVKVLSRN 321

  Fly   344 DKGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDTLIVVTADHAHVMSINGY 408
            .|||:|||||.|||..||...|..:|.:...|..|:::|.:||||.|||.:|||||:||.|..||
Mouse   322 PKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGY 386

  Fly   409 PYRDQEITGLAQL-ADDNLPYTILSYANGPGYYSGYNRAEGRALLKEKLVADSDYQYPTLAPLDA 472
            ..|...|.|||.| |.|..|||.:.|.|||||.....|....|...    :.|.|:.....|:.:
Mouse   387 TLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTAAES----SGSSYRQQAAVPVKS 447

  Fly   473 ETHGGDDVAVYASGPYAQYFSGNYEQSNIPALMARAAGIGPY 514
            |||||:|||::|.||.|....|..||:.|..:||.|..:.||
Mouse   448 ETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPY 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	210/462 (45%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	210/462 (45%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847875
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8508
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940