DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp6 and Alpl

DIOPT Version :9

Sequence 1:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	523	Identity:	225/523 - (43%)
Similarity:	289/523 - (55%)	Gaps:	54/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLVLAVCLSGSASGQRDHPRGRSFDAESHPIKYAEEQQTQYWVDKAQAKLLSKLAEQESATTNK 71
            |:|.:..||:            .||..|       :|:...||..:||..|.:.|..|: ..||.
Mouse     6 LVLAIGTCLT------------NSFVPE-------KERDPSYWRQQAQETLKNALKLQK-LNTNV 50

  Fly    72 AKNVILFLGDGMSVHTVTATRNLLG----DSAEQVYFE--GFPYTGLSKTYCVNRQVADSACTAT 130
            |||||:||||||.|.||||.|.|.|    ::.|:...|  .||:..|||||..|.||.|||.|||
Mouse    51 AKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTAT 115

  Fly   131 AYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASPAGVY 195
            |||.|||||.||:||:|...|..|:.....|  |.||..||:.|||..|:|||.||.||:|:..|
Mouse   116 AYLCGVKANEGTVGVSAATERTRCNTTQGNE--VTSILRWAKDAGKSVGIVTTTRVNHATPSAAY 178

  Fly   196 AHIADRNWENDWEVANRECDPEQTI----DIARQLVEQPVGQQLKVILGGGR-----KNFIDATV 251
            ||.|||:|.:|     .|..||...    |||.||:...  :.:.||:||||     ||..|...
Mouse   179 AHSADRDWYSD-----NEMPPEALSQGCKDIAYQLMHNI--KDIDVIMGGGRKYMYPKNRTDVEY 236

  Fly   252 NDEEGYPGKRTDGRHLIRSWLDQKKEANVSAKYVWSRKGLSLVDLENTDYLLGLFANDHLPYNGD 316
            ..:|...|.|.||..||..| ...|..:..:.|||:|..|..:|....|||||||....:.|
Mouse   237 ELDEKARGTRLDGLDLISIW-KSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQY--- 297

  Fly   317 RDRKRSQLADPSLSELTEAAITVLSRNDKGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQK 381
             :..|:.|.||||||:.|.|:.:|::|.|||||.|||.|||..||:..||::|.:..|..:|:.|
Mouse   298 -ELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGK 361

  Fly   382 ARELTSEDDTLIVVTADHAHVMSINGYPYRDQEITGLAQLAD--DNLPYTILSYANGPGYYSGYN 444
            |..:||:.|||.||||||:||.:..||..|...|.|||.:..  |..|:|.:.|.|||||.....
Mouse   362 AGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDG 426

  Fly   445 RAEGRALLKEKLVADSDYQYPTLAPLDAETHGGDDVAVYASGPYAQYFSGNYEQSNIPALMARAA 509
            ..|..:::.   .|.::||..:..||..|||||:||||:|.||.|....|.:||:.||.:||.|:
Mouse   427 ERENVSMVD---YAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAS 488

  Fly   510 GIG 512
            .||
Mouse   489 CIG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	206/455 (45%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	206/455 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847888
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910