DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and erc2

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	XP_009304519.1	Gene:	erc2 / 572002	ZFINID:	ZDB-GENE-130530-700	Length:	1131	Species:	Danio rerio

Alignment Length:	1403	Identity:	313/1403 - (22%)
Similarity:	507/1403 - (36%)	Gaps:	565/1403 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAHAMDYPRTRYQSLDRGGLVDPHD 101
            ||:.|......||| .|....|.||. .||.|:.|:|......:|:    ..|||:..
Zfish     2 YGSARAVGHIEGSP-ARSPRLPRSPR-LGHRRANSSSSGGKTLSME----NIQSLNAA------- 53

  Fly   102 REFIPIREPRDRSRDRSLERGLYLED-ELYGRSA----------RQSPSAM-GGYNTGMGPTSDR 154
                           .:....:||.| |..|.:|          |.:..|| ||..|.||.|.:.
Zfish    54 ---------------YATSGPMYLSDHEGVGSTATYPKGTMTLGRATSRAMYGGRVTAMGSTPNI 103

  Fly   155 AYLG----DLQ------------HQNT------------------------DLQRELGNLKRELE 179
            |.:|    |||            ||.|                        |:|||...|:|||:
Zfish   104 ATVGIPHADLQSYGDLGSLSLLHHQGTPSALLRQVVRGGGGELLELQAQLRDMQRENELLRRELD 168

  Fly   180 LTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQ--------KQAML-V 235
            |.:.|||||.:|||:||||||||||.:||||:|:.|::.:|:::...|||        |...| :
Zfish   169 LKDSKLGSSTNSIKSFWSPELKKERIMRKEEAARTSILKEQMRVTHEENQHLLDSRRTKHLQLTI 233

  Fly   236 RQLEEELRLRMRQPNLEMQQQMEA--------------------IYAENDHLQREISILRETIKD 280
            :.|::|||.: |..|..:||:..:                    :.||:|...:|:.:||:|:::
Zfish   234 QALQDELRTQ-RDLNHLLQQESSSRAGGGDHFTTIELTEENFRRLQAEHDRQAKELFLLRKTLEE 297

  Fly   281 LECRVETQKQTLIARDESIKKLLEMLQAKGM------GKEEERQMFQQMQAMAQKQMYNNYTGAS 339
            :|.|:|||||||.||||||||||||||:||:      ..:||.|...:..|.|:.|:
Zfish   298 MELRIETQKQTLGARDESIKKLLEMLQSKGLPPASGRASDEEEQERARRIAEAEAQL-------- 354

  Fly   340 GSSPPLPDIIGQYYGPGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQT 404

Zfish   355 ----------------------------------------------------------------- 354

  Fly   405 SPIRRRRYSIAGLPSATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQL 469
                                   |:....|.|....|| :|..|.|:           .||
Zfish   355 -----------------------GHLEVILDQKEKENI-HLREELHR-----------RNQ---- 380

  Fly   470 GQLVTTPLGGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQV 534
                                      |||.
Zfish   381 --------------------------LHPD----------------------------------- 384

  Fly   535 LPTQLTAAQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQ 599
             |.:..|.|:                ::....|..|:
Zfish   385 -PGKTKALQT----------------IIEMKDTKIAS---------------------------- 404

  Fly   600 RQLMAHQSLHASNPAISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQ 664

Zfish   405 ----------------------------------------------------------------- 404

  Fly   665 ASVQQQMHPQYQYHVHQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSH 729
                      .:.::...::.:|......|.||
Zfish   405 ----------LERNIRDLEDEIQMLKANGLLNT-------------------------------- 427

  Fly   730 PHHSSHHSHHTAYPHSHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEHKRQLDEFRLEIQRRD 794
                            ....::.:..:.:.:|    ||.          .|.::|:.:.|:.:::
Zfish   428 ----------------EDREEEIKQMEVYKNH----SKF----------MKTKIDQLKQELSKKE 462

  Fly   795 QEILAMAAKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQG 859
            .|:||:..|::||..|:.|.::||.||||||.|||:...:|||:|:.:|.|||||...:.|||:.
Zfish   463 SELLALQTKLETLNNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQ 527

  Fly   860 TLQTVQERNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHS 924
            .....:|:..|..|:.::||.:::|:|||:|||:|||||::.|::||.|:...:.|:.::|...|
Zfish   528 LQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLGNLKDRVKSLQTDSS 592

  Fly   925 SSEGALTSLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTR 989
            :::.||.:||||:.:||:.:.:|::||:|.:.|:.||.|.:::|..|.|          ||:.|
Zfish   593 NTDTALATLEEALSEKERIIERLKEQREREDRERMEELDSYKKENKDLK----------EKVNT- 646

  Fly   990 LERAVTERERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLE 1054
            |:..:||:|...|.|:...|.|..|..:.:                 .::..||:..|:.|.
Zfish   647 LQVELTEKESSLIDLKEHASSLASSGLKKD-----------------SKLKSLEIAIEQKKE--- 691

  Fly  1055 RSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQA-ELRVTQSDAERAREE 1118
                      |..|:.|              :.|::|::..:::...:| |:.|.||  .|...|
Zfish   692 ----------ECNKLET--------------QLQKQAEQLFSQMNNPKAHEVEVQQS--SRGNPE 730

  Fly  1119 AAALQEKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKIKEEME 1183
            .....:.|||   ||...|.:...||.|.|.|.:.|.:.::..:    |:|:...|:|.:.....
Zfish   731 YVDRVKLLEK---EVSYFKDESSKAQNEVERLLEILREVETEKN----DKDKKIQELESLAPRQT 788

  Fly  1184 RTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDK-----LDKACTENRRLVLEKEKLTYD-----Y 1238
            :.|...|..    .||...:|| :...:.|||:     :|....|....||||.:...|     .
Zfish   789 KDQIKKGPG----IKLGPQMDK-KGPGNILQDQRKDNPMDNPKMEELMNVLEKTRQELDATKQRL 848

  Fly  1239 DNLQSQLDKALGQAARMQKERETLSLDTDRIREKLE-KTQVQLGRI-QKERDQFSDELETLKERS 1301
            .:.|..|.:..|....:::||.      .::.|.|| |.|..|..| :|:.:....||.:..::.
Zfish   849 SSTQQSLSERDGHLTNLRQERR------KQLEEILEMKQQALLAAISEKDANIALLELSSSNKKK 907

  Fly  1302 ESAQTLLMKAARDR------EAMQTDLEVLKERYEKSH 1333
            ...:.|.:|..:||      :..|:.::::.:.||..|
Zfish   908 TQEEVLALKREKDRLMHQLKQQTQSRMKLIADNYEDDH 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	0/68 (0%)
		Myosin_tail_1	789..1824	CDD:279860	159/564 (28%)
		SMC_prok_B	1509..>2215	CDD:274008
		Bud13	2091..>2157	CDD:286779
erc2	XP_009304519.1	Cast	150..936	CDD:287183	268/1216 (22%)
erc2	XP_009304519.1	FAM76	<503..570	CDD:292665	30/66 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2153
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	LDO	PTHR18861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960