DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and ERC2

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	XP_016861627.1	Gene:	ERC2 / 26059	HGNCID:	31922	Length:	1001	Species:	Homo sapiens

Alignment Length:	1401	Identity:	300/1401 - (21%)
Similarity:	523/1401 - (37%)	Gaps:	543/1401 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SPGRVRRLQELPTV-DRSPSRDYGAPRGSPLAM-------------GSPYYRDMD---EPTSPAG 63
            ||.|..||...|.: .|..|...|...|..|:|             |..|..|.:   ..|.|.|
Human    14 SPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKG 78

  Fly    64 A---GHHRSRS---------ASRPPMAHA-MDYPRTRYQSLDRGGLV--DPHDREFIP--IREPR 111
            .   |...:|:         .|.|.:|.| :.:......:...|||.  ..|....:|  :|:.|
Human    79 TMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVR 143

  Fly   112 DRSRDRSLERGLYLEDELYGRSARQSPSAMGGYNTGMGPTSDRAYLGDLQHQNTDLQRELGNLKR 176
            |.:                                          :.|||.|..:||||...|::
Human   144 DST------------------------------------------MLDLQAQLKELQRENDLLRK 166

  Fly   177 ELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQ-------KQAML 234
            ||::.:.||||||:||||||||||||||.|||||:|:.|::.:|:::...|||       |...|
Human   167 ELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQLLDARRTKHLQL 231

  Fly   235 -VRQLEEELRLRMRQPNLEMQQQ-----------------MEAIYAENDHLQREISILRETIKDL 281
             ::.|::|||.: |..|..:||:                 ...:.||:|...:|:.:||:|::::
Human   232 TIQALQDELRTQ-RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 295

  Fly   282 ECRVETQKQTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLP 346
            |.|:|||||||.||||||||||||||:||:
Human   296 ELRIETQKQTLNARDESIKKLLEMLQSKGL----------------------------------- 325

  Fly   347 DIIGQYYGPGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRR 411
                                              ||.|.                 :....|.||
Human   326 ----------------------------------PSKSL-----------------EDDNERTRR 339

  Fly   412 YSIAGLPSATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTP 476
              :|...|...:.:|.      |.|....|| :|..|.|    |.||:.....:.:.|..::.
Human   340 --MAEAESQVSHLEVI------LDQKEKENI-HLREELH----RRSQLQPEPAKTKALQTVIE-- 389

  Fly   477 LGGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTA 541
                                              |:.::||:..|::.:|
Human   390 ----------------------------------MKEASSFNFDPDLVWQ--------------- 405

  Fly   542 AQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQ 606

Human   406 ----------------------------------------------------------------- 405

  Fly   607 SLHASNPAISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQM 671
                                  ....|:|..|::.                     ::..:|.
Human   406 ----------------------DTKIASLERNIRD---------------------LEDEIQM-- 425

  Fly   672 HPQYQYHVHQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHH 736
                               |.|        .|.|.:..|:
Human   426 -------------------LKA--------NGVLNTEDRE------------------------- 438

  Fly   737 SHHTAYPHSHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEHKRQLDEFRLEIQRRDQEILAMA 801
                      ...:|.:.:::|       ||.          .|.::|:.:.|:.:::.|:||:.
Human   439 ----------EEIKQIEVYKSH-------SKF----------MKTKIDQLKQELSKKESELLALQ 476

  Fly   802 AKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQE 866
            .|::||..|:.|.::||.||||||.|||:...:|||:|:.:|.|||||...:.|||:......:|
Human   477 TKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEE 541

  Fly   867 RNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALT 931
            :..|..|:.::||.:::|:|||:|||:|||||::.|::||.|:...:.|:.::|...|:::.||.
Human   542 KGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALA 606

  Fly   932 SLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTE 996
            :||||:.:||:.:.:|::||:|.:.|:.||.:...:|..|.|.|:.|.::|           :||
Human   607 TLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAE-----------LTE 660

  Fly   997 RERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQNVQK 1061
            :|...|.|:...|.|         |:..:.|.|        ::..||:..|:.|.:..:.:
Human   661 KESSLIDLKEHASSL---------ASAGLKRDS--------KLKSLEIAIEQKKEECSKLE---- 704

  Fly  1062 LMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERARE---EAAALQ 1123
                               :|...:|::..::........:.:.|:....|::.::   ||:..:
Human   705 -------------------AQLKKQAEQLFNQMYNPAHNIEDDSRMNPEFADQIKQLDKEASYYR 750

  Fly  1124 EKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFS------EVEKIK--- 1179
            ::..|:|.||.||...|:..:.|:....:::.:.:|...|...|:::..:      ::||.|
Human   751 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQ 815

  Fly  1180 --EEMERTQATL--GKSQLQHEKLQNSLDKAQNEVDHLQDKLDKACTENRRLVLEKEKLTYDYDN 1240
              ||:.|.:.::  ....||.|:|.|:|:|.:.|:|..:.:|    ...::.:.|||.   ...|
Human   816 LLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARL----ASTQQSLAEKEA---HLAN 873

  Fly  1241 LQSQLDKALGQAARMQKERETLSLD--------TDRIREKLEKTQVQLGRIQKERDQFSDELETL 1297
            |:.:..|.|.:...|::|....::.        .:....|.:|||.::..:::|:|:...:|
Human   874 LRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQL--- 935

  Fly  1298 KERSESAQTLLMKAARDREAMQTDLEVLKERYEKSH 1333
                             ::..|..::::.:.|:..|
Human   936 -----------------KQQTQNRMKLMADNYDDDH 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	3/68 (4%)
		Myosin_tail_1	789..1824	CDD:279860	144/569 (25%)
		SMC_prok_B	1509..>2215	CDD:274008
		Bud13	2091..>2157	CDD:286779
ERC2	XP_016861627.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4809
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2131
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	1	1.000	-	-		otm41752
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	LDO	PTHR18861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3525
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.890